Topographic and biomechanical comparison of diluted alcohol and iontophoresis-assisted versus accelerated corneal crosslinking in keratoconus

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dc.authorid0000-0001-8710-8871
dc.contributor.authorBektas, Caglar
dc.contributor.authorUysal, Betul Seher
dc.contributor.authorDiker, Hasan
dc.contributor.authorOzmen, Mehmet Cuneyt
dc.contributor.authorBilgihan, Kamil
dc.date.accessioned2026-02-03T12:00:34Z
dc.date.available2026-02-03T12:00:34Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPurpose To compare the corneal biomechanical characteristics following accelerated cross-linking (A-CXL) and diluted alcohol and iontophoresis-assisted corneal cross-linking (DAI-CXL). Methods Forty-nine eyes from 41 patients who underwent DAI-CXL or A-CXL for progressive keratoconus were included. Visual acuity, topographic, and biomechanical data were analyzed preoperatively and 12 months postoperatively. Results A significant decrease in flat keratometry (K1) and thinnest corneal thickness (TCT) was observed in the A-CXL group between baseline and postoperatively (K1, p = 0.001; TCT: p = 0.007). Both groups showed a significant decrease in steep keratometry (K2) and maximum keratometry (Kmax) compared to baseline (K2: p = 0.03, p < 0.001, respectively; Kmax: p < 0.001 for both groups). Postoperatively, highest concavity time (HCT) was significantly lower (p = 0.007), and highest concavity peak distance (HCPD) was significantly higher (p = 0.034) in the DAI-CXL group compared to the A-CXL group. A significant increase in applanation 1 velocity (A1V), HCPD, and deformation amplitude (DA) (p = 0.03, 0.007, 0.02, respectively) and a decrease in Ambrosio relational thickness to the horizontal profile (ARTh) (p < 0.001) were noted in the A-CXL group at 12 months. The DAI-CXL group showed a significant decrease in HCT, integrated radius (IR), and ARTh (p = 0.006, 0.011, 0.009, respectively) between baseline and postoperative assessments. Corvis Biomechanical Factor (CBiF) and E-stage remained stable in both groups. Conclusion DAI-CXL and A-CXL demonstrate comparable efficacy in achieving visual, topographic, and biomechanical stabilization in progressive keratoconus over a 12-month period.
dc.identifier.doi10.1177/11206721251364409
dc.identifier.endpage33
dc.identifier.issn1120-6721
dc.identifier.issn1724-6016
dc.identifier.issue1
dc.identifier.pmid40785319
dc.identifier.scopus2-s2.0-105013494379
dc.identifier.scopusqualityQ2
dc.identifier.startpage24
dc.identifier.urihttps://doi.org/10.1177/11206721251364409
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34648
dc.identifier.volume36
dc.identifier.wosWOS:001548115800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofEuropean Journal of Ophthalmology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectDiluted alcohol and iontophoresis-assisted corneal cross-linking
dc.subjecttransepithelial corneal cross-linking
dc.subjectcorneal biomechanics
dc.subjectCorvis ST
dc.subjectE-stage
dc.titleTopographic and biomechanical comparison of diluted alcohol and iontophoresis-assisted versus accelerated corneal crosslinking in keratoconus
dc.typeArticle

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