Gut Microbiota-Modulating Functions of Bovine Colostrum and Bovine Milk Oligosaccharides

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dc.authorid0000-0002-5286-2249
dc.authorid0000-0003-4056-1673
dc.authorid0000-0003-3353-0457
dc.contributor.authorYalcintas, Yalcin Mert
dc.contributor.authorDuman, Hatice
dc.contributor.authorBechelany, Mikhael
dc.contributor.authorBinmowyna, Mona N.
dc.contributor.authorRaposo, Antonio
dc.contributor.authorAhmad, Md Faruque
dc.contributor.authorAl Khairat, Muzaynah
dc.date.accessioned2026-02-03T12:02:21Z
dc.date.available2026-02-03T12:02:21Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe gut microbiome is a complex ecosystem composed of trillions of microorganisms that play vital roles in digestion, immune regulation, and overall health. Disruptions in this microbial balance are linked to various metabolic, inflammatory, and neurological disorders. Among dietary components that influence the gut microbiome, oligosaccharides derived from bovine colostrum and milk have gained increasing attention due to their bioactive properties. Bovine colostrum, the nutrient-rich fluid produced in the first days after parturition, contains a high concentration of structurally diverse oligosaccharides and glycoproteins that may selectively promote beneficial bacteria, such as Bifidobacterium species. These compounds are considered crucial to early-life microbial development and may exert prebiotic effects that support intestinal health. While human milk contains a broader variety of oligosaccharides, bovine colostrum and milk share several structurally similar compounds with relevant functions. Oligosaccharides from mature bovine milk have been more extensively studied regarding microbial interactions, enzymatic degradation, and metabolic fate. These findings provide valuable comparative insights into the functional roles of colostrum-derived oligosaccharides. This review highlights the modulatory effects of bovine colostrum and milk oligosaccharides on the gut microbiome, with particular emphasis on the unique contributions of colostrum.
dc.description.sponsorshipFundacao para a Ciencia e Tecnologia [PNURSP2025R130]
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University Researchers
dc.description.sponsorshipPrincess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
dc.description.sponsorshipThe author N.A.A. would like to thank Princess Nourah bint Abdulrahman University Researchers supporting project number (PNURSP2025R130), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
dc.identifier.doi10.1080/87559129.2025.2530657
dc.identifier.endpage2436
dc.identifier.issn8755-9129
dc.identifier.issn1525-6103
dc.identifier.issue8
dc.identifier.scopus2-s2.0-105010652351
dc.identifier.scopusqualityQ1
dc.identifier.startpage2421
dc.identifier.urihttps://doi.org/10.1080/87559129.2025.2530657
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34717
dc.identifier.volume41
dc.identifier.wosWOS:001526068500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofFood Reviews International
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectGlycoproteins
dc.subjectgut microbiome
dc.subjecthealth effects
dc.subjectimmune system
dc.subjectoligosaccharides
dc.titleGut Microbiota-Modulating Functions of Bovine Colostrum and Bovine Milk Oligosaccharides
dc.typeReview

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