Sclerotic effect of oxytetracycline on the submandibular gland: An experimental model

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dc.authoridArik, Deniz/0000-0003-0905-2731
dc.authoridMURATLI, Asli/0000-0003-1901-2477
dc.contributor.authorGuclu, Oguz
dc.contributor.authorMuratli, Asli
dc.contributor.authorArik, Deniz
dc.contributor.authorTekin, Kazim
dc.contributor.authorErdogan, Halil
dc.contributor.authorDerekoy, Fevzi Sefa
dc.date.accessioned2025-01-27T20:56:27Z
dc.date.available2025-01-27T20:56:27Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOxytetracycline has been suggested as an alternate therapy for chronic recurrent sialadenitis and sialorrhea. We conducted an experimental study to investigate the sclerotic effect of this drug on the submandibular gland by histopathologic methods. Our subjects were 20 New Zealand white rabbits, which were divided into two groups of 10. The right submandibular gland of the rabbits in the active treatment group was injected with 0.3 ml of oxytetracycline (100 mg/ml), and that of the controls was injected with saline. Four weeks after the injections, all the glands were removed. Histopathologic studies, including hematoxylin and eosin and Masson trichrome staining, were carried out. The glands were evaluated for tissue inflammation, congestion, fibrosis, edema, lipomatosis, and atrophy. To investigate apoptosis, terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick-end labeling (TUNEL) immunohistochemical staining was used. In the study group, inflammation (n = 9), congestion (n = 9), fibrosis (n = 6), edema (n = 6), and lipomatosis (n = 4) were observed; in the sham group, only lipomatosis was seen (n = 5). The TUNEL assay results for acinar cells were 4.51 +/- 1.41% in the oxytetracycline group and 2.08 +/- 1.76% in the control group (p = 0.006); the corresponding figures for the duct cells were 7.05 +/- 0.87% and 3.10 +/- 2.26% (p = 0.001). Based on our findings, we conclude that oxytetracycline might be a viable alternative for the treatment of chronic recurrent sialadenitis and sialorrhea. However, more research in this area is needed.
dc.identifier.doi10.1177/014556131609501210
dc.identifier.endpage496
dc.identifier.issn0145-5613
dc.identifier.issn1942-7522
dc.identifier.issue12
dc.identifier.pmid27929598
dc.identifier.scopus2-s2.0-85012253790
dc.identifier.scopusqualityQ2
dc.identifier.startpage492
dc.identifier.urihttps://doi.org/10.1177/014556131609501210
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26407
dc.identifier.volume95
dc.identifier.wosWOS:000389616700009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVendome Group Llc
dc.relation.ispartofEnt-Ear Nose & Throat Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectSclerotherapy
dc.subjectApoptosis
dc.subjectParotitis
dc.subjectMitosis
dc.subjectAtrophy
dc.titleSclerotic effect of oxytetracycline on the submandibular gland: An experimental model
dc.typeArticle

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