Plasma homocysteine levels in patients with keratoconus

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dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorArikan, Sedat
dc.contributor.authorTurkon, Hakan
dc.date.accessioned2025-01-27T20:43:46Z
dc.date.available2025-01-27T20:43:46Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground To compare the plasma levels of homocysteine between patients with keratoconus and healthy subjects. Methods Thirty-three keratoconus patients, and 47 age-gender matched healthy subjects were included in this prospective study. The plasma level of homocysteine, folic acid, and vitamin B12 was assessed using the chemiluminescence immunometric method. According to the manufacturer's instructions, the normal plasma level of homocysteine, vitamin B12 and folic acid was accepted as <= 13 mu m/L, 191-663 pg/mL, and 4.6-18.7 ng/mL respectively. Mann-Whitney U and Spearman's correlation tests were used for pairwise comparisons and correlation analysis, respectively. Results There was a statistically significant difference between keratoconus patients and healthy subjects in terms of mean plasma level of homocysteine (15.02 +/- 8.01 mu m/l in keratoconus patients versus 12.62 +/- 8.17 mu m/l in healthy subjects, p = 0.01). However, the mean plasma level of either vitamin B12 (263.78 +/- 107.2 pg/ml in keratoconus patients versus 264.78 +/- 94.2 pg/ml in healthy subjects, p = 0.3), or folic acid (5.98 +/- 3.2 ng/ml in keratoconus patients versus 6.72 +/- 3.1 ng/ml in healthy subjects, p = 0.1) were not statistically significantly different between two groups. A negative correlation was found between plasma homocysteine level and central corneal thickness (p < 0.001). A positive correlation was found between plasma homocysteine level and steepest keratometry (p = 0.004) and average Sim-K (p = 0.002). Conclusions The increased plasma level of homocysteine in keratoconus patients may either arise from a consequence of biochemical events such as oxidative stress, or it may contribute to the pathogenesis or progression of keratoconus by chelating copper, which is an important co-factor of lysyl oxidase enzyme taking place in corneal collagen crosslinking.
dc.identifier.doi10.1111/cxo.13044
dc.identifier.endpage807
dc.identifier.issn0816-4622
dc.identifier.issn1444-0938
dc.identifier.issue6
dc.identifier.pmid32036622
dc.identifier.scopus2-s2.0-85079121703
dc.identifier.scopusqualityQ2
dc.identifier.startpage804
dc.identifier.urihttps://doi.org/10.1111/cxo.13044
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24363
dc.identifier.volume103
dc.identifier.wosWOS:000582460900013
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofClinical and Experimental Optometry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectfolic acid
dc.subjecthomocysteine
dc.subjectkeratoconus
dc.subjectplasma
dc.subjectvitamin B12
dc.titlePlasma homocysteine levels in patients with keratoconus
dc.typeArticle

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