Evaluation of upper endoscopic findings in patients with restless legs syndrome and gastric complaints

Basit Öğe Kaydı
dc.authoridKUTLUANA, UFUK/0000-0002-2323-5756
dc.authoridCAM, MUSTAFA/0000-0003-3116-203X
dc.contributor.authorCam, Mustafa
dc.contributor.authorKutluana, Ufuk
dc.date.accessioned2025-01-27T20:41:02Z
dc.date.available2025-01-27T20:41:02Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The effect of gastrointestinal system disorders on Restless Legs Syndrome/Willis-Ekbom disease (RLS/WED) has been previously demonstrated by using serological tests. However, this association has not been supported by histopathological studies so far. Objective: To investigate the relationship between RLS/WED, upper endoscopic imaging and histopathological results in patients diagnosed with RLS who underwent endoscopy because of gastrointestinal system (GIS) complaints. Methods: Case-control study, including 100 patients diagnosed with RLS who presented dyspeptic complaints and underwent upper GIS endoscopy and 106 age- and sex-matched controls. RLS diagnosis was evaluated according to the four main diagnostic criteria determined by the International RLS Study Group. All patients underwent upper GIS endoscopic intervention and at least one gastric and/or antral biopsy. Results: There was no significant difference between patients and controls in relation to endoscopically seen gastric ulcer, duodenal ulcer, gastroesophageal reflux disease (GERD) findings and Helicobacter pylori (HP) positivity (p>0.05). Intestinal metaplasia and mucosal atrophy were more common in RLS/WED patients compared to controls (p=0.026 and p=0.017, respectively). Additionally, ferritin levels were found to be lower than the reference value. Conclusions: The detection of increased severity of intestinal metaplasia, mucosal atrophy, and gastric inflammation in RLS/WED patients with dyspeptic complaints may entail the close gastrointestinal system evaluation of these patients. However, larger randomized and controlled trials are required on this subject where patients are evaluated by upper GIS endoscopic biopsy.
dc.identifier.doi10.1590/0004-282X20190192
dc.identifier.endpage223
dc.identifier.issn0004-282X
dc.identifier.issn1678-4227
dc.identifier.issue4
dc.identifier.pmid32294750
dc.identifier.scopus2-s2.0-85085751950
dc.identifier.scopusqualityQ3
dc.identifier.startpage217
dc.identifier.urihttps://doi.org/10.1590/0004-282X20190192
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23978
dc.identifier.volume78
dc.identifier.wosWOS:000530031200006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAssoc Arquivos Neuro- Psiquiatria
dc.relation.ispartofArquivos De Neuro-Psiquiatria
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectferritin
dc.subjectHelicobacter pylori
dc.subjectRLS
dc.subjectsleep disorder
dc.subjectatrophic gastritis
dc.subjectintestinal metaplasia
dc.subjectendoscopy
dc.titleEvaluation of upper endoscopic findings in patients with restless legs syndrome and gastric complaints
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu