Poly(Vinylamine) Derived N-Doped C-Dots with Antimicrobial and Antibiofilm Activities

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dc.authorid0000-0001-8666-7954en_US
dc.authorid0000-0002-3524-0675en_US
dc.authorid0000-0001-7083-1481en_US
dc.authorid0000-0003-0120-530Xen_US
dc.authorscopusid24472372400en_US
dc.authorscopusid57205727564en_US
dc.authorscopusid56026625600en_US
dc.authorscopusid6602001525en_US
dc.authorwosidAAB-6714-2020en_US
dc.authorwosidU-5886-2019en_US
dc.authorwosidU-5844-2019en_US
dc.authorwosidDVD-0927-2022en_US
dc.contributor.authorSutekin, Semiha Duygu
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSuner, Selin Sağbaş
dc.contributor.authorDemirci, Şahin
dc.contributor.authorGüven, Olgun
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2023-03-27T08:13:57Z
dc.date.available2023-03-27T08:13:57Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractNitrogen-doped carbon dots (N-doped C-dots) was synthesized by using poly(vinyl amine) (PVAm) as a nitrogen source and citric acid (CA) as a carbon source via the hydrothermal method. Various weight ratios of CA and PVAm (CA:PVAm) were used to synthesize N-doped C-dots. The N-doped C-dots revealed emission at 440 nm with excitation at 360 nm and were found to increase the fluorescence intensity with an increase in the amount of PVAm. The blood compatibility studies revealed no significant hemolysis for N-doped C-dots that were prepared at different ratios of CA:PVAm for up to 500 μg/mL concentration with the hemolysis ratio of 1.96% and the minimum blood clotting index of 88.9%. N-doped C-dots were found to be more effective against Gram-positive bacteria than Gram-negative bacteria, with the highest potency on Bacillus subtilis (B. subtilis). The increase in the weight ratio of PVAm in feed during C-dots preparation from 1 to 3 leads to a decrease of the minimum bactericidal concentration (MBC) value from 6.25 to 0.75 mg/mL for B. subtilis. Antibiofilm ability of N-doped C-dots prepared by 1:3 ratio of CA:PVAm was found to reduce %biofilm inhibition and eradication- by more than half, at 0.78 mg/mL for E. coli and B. subtilis generated biofilms and almost destroyed at 25 mg/mL concentrations.en_US
dc.identifier.citationSutekin, S. D., Şahiner, M., Suner, S. S., Demirci, S., Güven, O., & Sahiner, N. (2021). Poly(Vinylamine) Derived N-Doped C-Dots with Antimicrobial and Antibiofilm Activities. C-Journal of Carbon Research, 7(2), 40. https://doi.org/10.3390/c7020040 ‌en_US
dc.identifier.doi10.3390/c7020040
dc.identifier.issn2311-5629
dc.identifier.issue2en_US
dc.identifier.urihttps://doi.org/10.3390/c7020040
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3845
dc.identifier.volume7en_US
dc.identifier.wosWOS:000665199900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorSuner, Selin Sağbaş
dc.institutionauthorDemirci, Şahin
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPI (Multidisciplinary Digital Publishing Institute)en_US
dc.relation.ispartofC — Journal of Carbon Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectPoly (vinylamine)en_US
dc.subjectN-doped C-dotsen_US
dc.subjectBlood compatibiityen_US
dc.subjectAntimicrobial/antibiofilmen_US
dc.titlePoly(Vinylamine) Derived N-Doped C-Dots with Antimicrobial and Antibiofilm Activities
dc.typeArticle

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