Evaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance

Basit Öğe Kaydı
dc.authoridYilmaz, Nafiye/0000-0002-4041-297X
dc.contributor.authorBeyazit, Fatma
dc.contributor.authorYilmaz, Nafiye
dc.contributor.authorBalci, Osman
dc.contributor.authorAdam, Magdi
dc.contributor.authorYaman, Selen Taflan
dc.date.accessioned2025-01-27T20:46:04Z
dc.date.available2025-01-27T20:46:04Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective Ischemia-mediated oxidative stress and inflammation have been reported to be important contributors to the pathogenesis of polycystic ovary syndrome (PCOS). Ischemia-modified albumin (IMA) is a novel marker generated under ischemic and oxidative conditions and may reflect disease activity in distinct disease states. Therefore, we investigated whether the serum IMA levels are affected in infertile PCOS patients. Methods Forty-six patients with infertile PCOS, 30 patients with unexplained infertility, and 31 age-and body mass index (BMI)-matched controls were included in this cross-sectional study. Biochemical parameters, serum IMA levels, and their correlations with serum testosterone and insulin resistance were determined for each subject. Results In patients with infertile PCOS, the serum IMA levels were significantly elevated (p=0.003) compared with unexplained infertility patients and controls. A correlation analysis suggested that the IMA levels only correlated with the serum free testosterone levels in PCOS patients (r=0.43, p=0.028). Conclusion Elevations in the serum IMA levels in infertile PCOS patients may suggest a possible additional role of oxidative stress mechanisms in disease pathophysiology. Moreover, correlation between serum IMA and testosterone levels may influence the quality of oocytes via alterations in the balance of critical follicular fluid factors in the follicular microenvironment.
dc.identifier.doi10.2169/internalmedicine.55.6265
dc.identifier.endpage2364
dc.identifier.issn0918-2918
dc.identifier.issn1349-7235
dc.identifier.issue17
dc.identifier.pmid27580534
dc.identifier.scopus2-s2.0-84984865441
dc.identifier.scopusqualityQ3
dc.identifier.startpage2359
dc.identifier.urihttps://doi.org/10.2169/internalmedicine.55.6265
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24799
dc.identifier.volume55
dc.identifier.wosWOS:000383017300005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJapan Soc Internal Medicine
dc.relation.ispartofInternal Medicine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectpolycystic ovary syndrome
dc.subjectunexplained infertility
dc.subjectischemia-modified albumin
dc.subjectinsulin
dc.subjecttestosterone
dc.titleEvaluation of Oxidative Stress in Women with Polycystic Ovarian Syndrome as Represented by Serum Ischemia Modified Albumin and Its Correlation with Testosterone and Insulin Resistance
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu