The effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridCoskun, Hamit/0000-0002-5509-8717
dc.authoridGunduz, Bulent/0000-0003-0497-8287
dc.contributor.authorKarakas, Alper
dc.contributor.authorCoskun, Hamit
dc.contributor.authorKaya, Aliye
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorGunduz, Bulent
dc.date.accessioned2025-01-27T21:02:13Z
dc.date.available2025-01-27T21:02:13Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn the present study, the effects of intraamygdalar administrations of melatonin (1 and 100 mu g/kg), saline and diazepam on the anxiety-like behavior and spatial memory performance in pinealectomized and sham-pinealectomized Wistar rats were investigated. The animals were tested by open field and elevated plus maze tests for anxiety-like behavior, and Morris water maze test for spatial memory. In open field, (a) diazepam was more effective in reducing the anxiety, (b) control subjects were more mobile than pinealectomized subjects and (c) 100 mu g/kg melatonin administrations reduced the velocity of the animals. In elevated plus maze, (a) 100 mu g/kg melatonin administrations increased the distance totally travelled and (b) enhanced the time spent in open arms, however, after the pinealectomy, 1 mu g/kg melatonin administrations decreased it and (c) control animals were less mobile than pinealectomized ones. In Morris water maze, (a) diazepam group travelled more distance than the others in control condition whereas, in pinealectomy condition high dose of melatonin and saline groups travelled more distance than the others, (b) in pinealectomy condition subjects who received 100 mu g/kg melatonin also travelled more distance than those who received 1 mu g/kg melatonin and diazepam, (c) the subjects who received 1 mu g/kg spent less time than those who received other treatments, and (d) in control condition subjects who received 100 mu g/kg melatonin were slower than those who received the other treatments. In conclusion, melatonin administration to amygdala decreased the anxiety; however, spatial memory performance of the rats was impaired by the pinealectomy and melatonin administrations. (C) 2011 Elsevier B.V. All rights reserved.
dc.description.sponsorshipAIBU [2009.03.01.310]
dc.description.sponsorshipThis study was supported by the AIBU Scientific Research Project 2009.03.01.310.
dc.identifier.doi10.1016/j.bbr.2011.03.029
dc.identifier.endpage150
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549
dc.identifier.issue1
dc.identifier.pmid21421010
dc.identifier.scopus2-s2.0-79955786175
dc.identifier.scopusqualityQ2
dc.identifier.startpage141
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2011.03.029
dc.identifier.urihttps://hdl.handle.net/20.500.12428/27309
dc.identifier.volume222
dc.identifier.wosWOS:000291418400018
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofBehavioural Brain Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPineal gland
dc.subjectMelatonin
dc.subjectAmygdala
dc.subjectAnxiety
dc.subjectMemory
dc.titleThe effects of the intraamygdalar melatonin injections on the anxiety like behavior and the spatial memory performance in male Wistar rats
dc.typeArticle

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