The Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats

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dc.authoridKaravelioglu, Ergun/0000-0002-6611-1032
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.contributor.authorGuven, Mustafa
dc.contributor.authorYuksel, Yasemin
dc.contributor.authorSehitoglu, Muserref Hilal
dc.contributor.authorTokmak, Mehmet
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorAkman, Tarik
dc.contributor.authorGolge, Umut Hatay
dc.date.accessioned2025-01-27T20:50:20Z
dc.date.available2025-01-27T20:50:20Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe aim of the study was to determine the effect of coumaric acid on sciatic nerve ischemia/reperfusion (SNI) injury in rats. The rats were randomly divided into four groups: control group (no medication or surgical procedure), SNI group, SNI + coumaric acid (CA) group, and SNI + methylprednisolone (MP) group. Ischemia was achieved by abdominal aorta clamping, and all animals were sacrificed 24 h after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. A significant decrease in MDA, an increase in NRF1 levels, and increase in SOD activity were observed in the groups which received coumaric acid and methylprednisolone when compared to the corresponding untreated group (p < 0.05). Ischemic fiber degeneration significantly reduced in the SNI + CA and SNI + MP groups, especially in the SNI + MP group, compared to the SNI group (p < 0.05). Beta amyloid protein expressions were significantly decreased in the SNI + CA group compared to the SNI group (p < 0.05). Our study revealed that coumaric acid treatment after ischemia/reperfusion in rat sciatic nerves reduced oxidative stress and axonal degeneration. Therefore, coumaric acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
dc.identifier.doi10.1007/s10753-015-0195-0
dc.identifier.endpage2132
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue6
dc.identifier.pmid26049410
dc.identifier.scopus2-s2.0-84946482329
dc.identifier.scopusqualityQ1
dc.identifier.startpage2124
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0195-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25470
dc.identifier.volume38
dc.identifier.wosWOS:000364223800013
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectcoumaric acids
dc.subjectmethylprednisolone
dc.subjectsciatic nerve
dc.subjectreperfusion injury
dc.subjectsuperoxide dismutase
dc.subjectmalondialdehyde
dc.subjectnuclear respiratory factor 1
dc.titleThe Effect of Coumaric Acid on Ischemia-Reperfusion Injury of Sciatic Nerve in Rats
dc.typeArticle

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