Melatonin Improves Left Ventricular Mitochondrial Dynamics in Rats

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dc.authoriduzun, metehan/0000-0003-1406-5473
dc.authoridOztopuz, Ozlem/0000-0002-1373-6311
dc.authoridEROGLU, Huseyin Avni/0000-0002-1040-3255
dc.authoridDemir, Ufuk/0000-0002-0020-1633
dc.contributor.authorUzun, Metehan
dc.contributor.authorOztopuz, Ozlem
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorDemir, Ufuk
dc.date.accessioned2025-01-27T20:20:17Z
dc.date.available2025-01-27T20:20:17Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThere is increasing awareness that efficient and regular mitochondrial dynamics improvement cardiac function and affects the quality of life. Melatonin is a main pineal gland hormones and ameliorates mitochondrial dynamics in many cardiac disorders. For that purpose, we administrated melatonin to healthy rats all day long in order to investigate change in left ventricle mitochondrial dynamics both in the end of the nighttime and daytime. Twenty male Wistar rats (3-4 months age) were randomly assigned into Control (C; n = 10) and Melatonin groups (MEL; 10 mg/kg melatonin added drinking water, n = 10). On the 5th day of the study, 5 rats from the groups were randomly selected and euthanized at 08:00 AM and the remaining 5 rats were euthanized at 20:00 PM from each groups and samples of left ventricle (LV) tissue were harvested. Quantitative real-time PCR and western blot analysis demonstrated that melatonin acts preventive role on mitochondrial fusion and mitophagy through the DRP1/FIS1 and BNIP3/NIX axis, respectively. Additionally, melatonin administration significantly reduced P21 activation, induced cell cycle arrest, P27, finally regulated caspase-depended mitochondrial apoptosis signals in a time dependent manner. Our results suggest that melatonin may emerge as a therapeutic candidate to protect the bioenergetic dynamics of mitochondria in hearth.
dc.description.sponsorshipCanakkale Onsekiz Mart University Scientific Research Projects [TSA-2018-1346]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University Scientific Research Projects with project number TSA-2018-1346.
dc.identifier.doi10.3103/S0095452722020116
dc.identifier.endpage195
dc.identifier.issn0095-4527
dc.identifier.issn1934-9440
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85128482542
dc.identifier.scopusqualityQ3
dc.identifier.startpage185
dc.identifier.urihttps://doi.org/10.3103/S0095452722020116
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21654
dc.identifier.volume56
dc.identifier.wosWOS:000784966300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPleiades Publishing Inc
dc.relation.ispartofCytology and Genetics
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectKeywords
dc.subjectmelatonin
dc.subjectheart
dc.subjectapoptosis
dc.subjectmitochondrial dynamics
dc.subjectmitophagy
dc.titleMelatonin Improves Left Ventricular Mitochondrial Dynamics in Rats
dc.typeArticle

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