Multifunctional tunable p(inulin) microgels

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorSağbaş, Selin
dc.date.accessioned2025-01-27T20:55:57Z
dc.date.available2025-01-27T20:55:57Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractInulin, inulin-silica and modified inulin microgels were prepared in a single step via crosslinking within microemulsion, and used as drug delivery devices. Inulin-silica composite micro particles were also synthesized in the presence of tetraethyl orthosilicate (TEOS) via a water-in-oil microemulsion polymerization/crosslinking technique. To generate porous inulin particles, inulin-silica particles were treated with 0.5 M NaOH solution to dissolve silica particles. Furthermore, virgin inulin (p(inulin)) and porous inulin microgels (por-p(inulin)) were quaternized successfully by treatment with 3-chloro-2-hydroxypropyl trimethyl ammonium chloride (CHPTMAC) in aqueous solution, generating positive charges on the biopolymer as q-p(inulin). Rosmarinic acid (RA) was used as model drug for loading and release studies by synthesized inulin-based microgels in phosphate buffer solution (PBS) at pH 7.4. It was shown that the absorption and release rate are influenced by zeta potential and porosity of the microgels. (C) 2014 Elsevier B.V. All rights reserved.
dc.description.sponsorshipCouncil of Higher Education of Turkey; Turkish Academy of Science
dc.description.sponsorshipN. Sahiner is grateful to the Council of Higher Education of Turkey for the partial support, and also the Turkish Academy of Science under 2008 TUBA-GEBIP Program. Also, great support from L. Andrew Lyon is appreciated greatly.
dc.identifier.doi10.1016/j.msec.2014.04.028
dc.identifier.endpage372
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.pmid24857504
dc.identifier.scopus2-s2.0-84899671372
dc.identifier.scopusqualityN/A
dc.identifier.startpage366
dc.identifier.urihttps://doi.org/10.1016/j.msec.2014.04.028
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26252
dc.identifier.volume40
dc.identifier.wosWOS:000338388400047
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofMaterials Science and Engineering C-Materials For Biological Applications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectP(inulin) microgel
dc.subjectModified inulin microgel/nanogel
dc.subjectPorous p(inulin) microgel
dc.subjectNatural polymeric microgel
dc.titleMultifunctional tunable p(inulin) microgels
dc.typeArticle

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