New peripherally and non-peripherally tetra-substituted water soluble zinc phthalocyanines: Synthesis, photophysics and photochemistry

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dc.authoridcakir, volkan/0000-0002-5817-0817
dc.authoridPiskin, Mehmet/0000-0002-4572-4905
dc.authoridBiyiklioglu, Zekeriya/0000-0001-5138-214X
dc.contributor.authorCakir, Volkan
dc.contributor.authorCakir, Dilek
dc.contributor.authorPiskin, Mehmet
dc.contributor.authorDurmus, Mahmut
dc.contributor.authorBiyiklioglu, Zekeriya
dc.date.accessioned2025-01-27T20:38:38Z
dc.date.available2025-01-27T20:38:38Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe synthesis and photochemical properties of peripherally and non-peripherally 1,3-bis[3-(dimethy-lamino)phenoxy]prop-2-oxy tetra-substituted zinc phthalocyanines (2a and 3a) and their quaternized derivatives (2b and 3b) were reported in this study. Photochemical properties of quaternized ionic zinc (II) phthalocyanines (2b and 3b) were investigated in both dimethyl sulfoxide (DMSO) and aqueous solutions, while non ionic derivatives were only studied in DMSO. The quaternized compounds exhibit excellent solubility in water, making them potential photosensitizers for use in photodynamic therapy (PDT) of cancer. This study also showed that the water-soluble quaternized Zn(II) phthalocyanines strongly bind to blood plasma proteins such as bovine serum albumin (BSA). On the other hand, the interactions of the novel water soluble phthalocyaines with DNA were also examined. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific & Technological Research Council of Turkey (TUBITAK) [111T963]
dc.description.sponsorshipThis study was supported by The Scientific & Technological Research Council of Turkey (TUBITAK, project no: 111T963).
dc.identifier.doi10.1016/j.jorganchem.2015.02.021
dc.identifier.endpage129
dc.identifier.issn0022-328X
dc.identifier.issn1872-8561
dc.identifier.scopus2-s2.0-84924389976
dc.identifier.scopusqualityQ2
dc.identifier.startpage120
dc.identifier.urihttps://doi.org/10.1016/j.jorganchem.2015.02.021
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23679
dc.identifier.volume783
dc.identifier.wosWOS:000351638100018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Sa
dc.relation.ispartofJournal of Organometallic Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectZinc
dc.subjectPhthalocyanine
dc.subjectWater soluble
dc.subjectPhotodynamic therapy
dc.subjectBSA binding
dc.subjectDNA interaction
dc.titleNew peripherally and non-peripherally tetra-substituted water soluble zinc phthalocyanines: Synthesis, photophysics and photochemistry
dc.typeArticle

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