Liver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease

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dc.contributor.authorAkbal, Erdem
dc.contributor.authorKocak, Erdem
dc.contributor.authorAkyurek, Omer
dc.contributor.authorKoklu, Seyfettin
dc.contributor.authorBatgi, Hikmetullah
dc.contributor.authorSenes, Mehmet
dc.date.accessioned2025-01-27T20:44:22Z
dc.date.available2025-01-27T20:44:22Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractLiver fatty acid-binding protein (L-FABP) is a small cytoplasmic protein. The aim of the current study was to investigate L-FABP levels and to determine their diagnostic value for non-alcoholic fatty liver disease (NAFLD). We enrolled in this study 24 consecutive patients with NAFLD who were diagnosed with elevated transaminases and with steatosis by ultrasonograph. The control group consisted of 22 healthy control subjects matched for age and gender. Serum levels of L-FABP were determined by enzyme-linked immunosorbent assay. L-FABP levels in NAFLD patients were higher than in the control group (levels were 41,976 +/- 18,998 and 17048 +/- 5021 pg/mL, respectively). A strong correlation was found between serum L-FABP concentrations and aspartate aminotransferase, alanine aminotransferase, body mass index, glucose and gamma-glutamyltransferase levels. A level of 284,000 pg/mL L-FABP had 73 % sensitivity and 100 % specificity. Positive and negative predictive values for L-FABP were 100 and 79%, respectively. Serum L-FABP can be considered as a new diagnostic marker for detecting non-alcoholic fatty liver disease.
dc.identifier.doi10.1007/s00508-014-0680-8
dc.identifier.endpage52
dc.identifier.issn0043-5325
dc.identifier.issn1613-7671
dc.identifier.issue1-2
dc.identifier.pmid25447969
dc.identifier.scopus2-s2.0-84957430798
dc.identifier.scopusqualityQ1
dc.identifier.startpage48
dc.identifier.urihttps://doi.org/10.1007/s00508-014-0680-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24548
dc.identifier.volume128
dc.identifier.wosWOS:000369316900010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Wien
dc.relation.ispartofWiener Klinische Wochenschrift
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectNon-alcoholic fatty liver disease
dc.subjectLiver fatty acid-binding protein
dc.titleLiver fatty acid-binding protein as a diagnostic marker for non-alcoholic fatty liver disease
dc.title.alternativeFettsäurebindungsprotein als diagnostischer Marker einer nicht-alkoholischen Fettlebererkrankung
dc.typeArticle

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