Effect of resveratrol in acute hypoxic pulmonary vasoconstriction in isolated lamb pulmonary arteries and veins

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dc.contributor.authorSilan, Coşkun
dc.contributor.authorKuşcuo?lu, Evren
dc.contributor.authorUzun, Özge
dc.contributor.authorBalbay, Öner
dc.date.accessioned2025-01-27T19:04:03Z
dc.date.available2025-01-27T19:04:03Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractResveratrol (RSV) is a natural phytoalexin with many biological effects, including antioxidant, anti- platelet, anti- atherogenic, anti- inflamatory, estrogenic properties, immunomodulation and chemoprevention. In the cardiovascular system, it has been shown to cause relaxation of vascular smooth muscle, and reports indicate that RSV induces vasodilatory effects in several vascular beds by acting in endothelium dependent and independent manners. The aim of the study was to determine the role of RSV on hypoxia induced vasoconstriction in precontracted isolated pulmonary arteries and veins. Isolated lamb pulmonary vessels were suspended in an organ bath filled with Krebs Heinseleit solution and isolated contractions were recorded continuously via an isometric transducer connected to a computerized polygraph system. The solution was aerated with room air or a gas mixture of 95% N2 + 5% CO2 (hypoxic). The oxygen concentration of the bathing medium was measured using an oxygen electrode. Serotonin (5-HT)(10-5 M) for arteries and U46619, a thromboxane analog (TXA2) for veins, were used as pre contractile agents. Our results showed that in the presence of RSV (20 ?M), hypoxia induced pulmonary vasoconstriction decreased in pulmonary veins pre contracted with U46619, but not in pulmonary arteries pre contracted with 5-HT.
dc.identifier.endpage845
dc.identifier.issn1300-6045
dc.identifier.issue6
dc.identifier.scopus2-s2.0-72049132931
dc.identifier.scopusqualityQ3
dc.identifier.startpage841
dc.identifier.trdizinid94873
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/94873
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13775
dc.identifier.volume15
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_Scopus_20250125
dc.subject5-ht; Hypoxia; Pulmonary vasoconstriction; Resveratrol; U46619
dc.titleEffect of resveratrol in acute hypoxic pulmonary vasoconstriction in isolated lamb pulmonary arteries and veins
dc.title.alternativeResveratrolün i?zole kuzu pulmoner arter ve venlerinde akut hipoksik pulmoner vazokonstrüksiyona etkileri
dc.typeArticle

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