The preparation of various shapes and porosities of hydroxyethyl starch/p(HEMA-co-NVP) IPN hydrogels as programmable carrier for drug delivery

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dc.authoridOzay, Hava/0000-0002-4184-7801
dc.contributor.authorÖzay, Özgür
dc.contributor.authorIlgin, Pinar
dc.contributor.authorOzay, Hava
dc.contributor.authorGungor, Zeynep
dc.contributor.authorYilmaz, Betul
dc.contributor.authorKivanc, Mehmet Riza
dc.date.accessioned2025-01-27T20:22:49Z
dc.date.available2025-01-27T20:22:49Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis study used biocompatible and biodegradable hydroxyethyl starch (HES), 2-hydroxyethyl methacrylate (HEMA) and N-vinyle-2-pyrrolidone (NVP) monomers for hydrogel synthesis with the aim of use as a drug carrier system. As a result of the synthesis reactions using the redox polymerization technique, hydrogels were produced in both film and cylindrical form. The morphological characterization and structural characterization of hydrogels were performed using scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FT-IR), respectively. In addition, swelling characterizations of hydrogels to be used for drug release in various media were examined. The release properties of sodium diclofenac (NaDc) and trimethoprim (TMP) loaded into hydrogels produced in order to use as drug carrier material for controlled drug release were examined in media with pH = 1.2 and 7. It was determined that the hydrogels performed controlled release according to the type of drug and the pH values of the medium. Drug release mechanisms deviated from Fickian mode according to determined drug release rate constants, diffusion exponent (n) and regression values at different pH values. In addition, antibacterial properties of drug-loaded hydrogels against B. subtilus, S. aureus and E. coli were investigated.
dc.identifier.doi10.1080/10601325.2019.1700803
dc.identifier.endpage387
dc.identifier.issn1060-1325
dc.identifier.issn1520-5738
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85076410047
dc.identifier.scopusqualityQ2
dc.identifier.startpage379
dc.identifier.urihttps://doi.org/10.1080/10601325.2019.1700803
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22037
dc.identifier.volume57
dc.identifier.wosWOS:000502213400001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofJournal of Macromolecular Science Part A-Pure and Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDrug release
dc.subjecthydrogel
dc.subjectantibacterial
dc.subjecthydroxyethyl starch
dc.subject2-hydroxyethyl methacrylate
dc.subjectN-vinyl-2-pyrrolidone
dc.titleThe preparation of various shapes and porosities of hydroxyethyl starch/p(HEMA-co-NVP) IPN hydrogels as programmable carrier for drug delivery
dc.typeArticle

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