Curcumin as a modulator of IL-18: A promising therapeutic approach for inflammatory diseases

Basit Öğe Kaydı
dc.authorid0000-0003-4056-1673
dc.contributor.authorKaviani, Maryam
dc.contributor.authorGhoflchi, Sahar
dc.contributor.authorDisfani, Saba Miri
dc.contributor.authorJalili-Nik, Mohammad
dc.contributor.authorSadeghi, Asie
dc.contributor.authorKarav, Sercan
dc.contributor.authorKesharwani, Prashant
dc.date.accessioned2026-02-03T12:02:44Z
dc.date.available2026-02-03T12:02:44Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractInflammatory and immune-related pathways act as a central mediator in the pathogenesis of a wide range of diseases, including cancer, cardiovascular diseases, kidney disorders, acute lung injury, autoimmune conditions, and neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. The activation of the NACHT, LRR and PYD domain-containing protein 3 (NLRP3) inflammasome, a key component of innate immunity, promotes inflammation through the release of interleukin (IL)-18. By enhancing the production of other pro-inflammatory cytokines like interferon (IFN)-gamma and facilitating T-helper cell polarization, IL-18 amplifies the inflammatory cascade. Research indicates that curcumin effectively suppresses IL-18 production and modulates signaling pathways that contribute to its activation, including the nuclear factor kappa B (NF-kappa B) and NLRP3 inflammasome pathways. NF-kappa B, a master regulator of inflammation, is directly influenced by curcumin, which inhibits its translocation to the nucleus, thereby downregulating the expression of IL-18 and other inflammatory mediators. By targeting upstream regulators and components of the inflammasome, curcumin reduces pyroptosis, oxidative stress, and cytokine storm-like responses, offering a multifaceted therapeutic approach. The role of curcumin in modulating oxidative stress and immune responses positions it as a promising adjunct or alternative therapeutic agent for diseases linked to IL-18 dysregulation. Preclinical and clinical studies have further demonstrated synergistic effects when combined with conventional therapies. This highlights its potential not only in mitigating disease progression but also in addressing underlying inflammatory processes such as chronic inflammatory disease, cardiovascular disease, and neurodegenerative disease. Given these attributes, targeting IL-18 with curcumin-based interventions is the way for novel therapeutic strategies that balance efficacy with minimal side effects, addressing both symptoms and underlying disease mechanisms.
dc.description.sponsorshipDeputy of Research, Kerman University of Medical Sciences [403001123]
dc.description.sponsorshipThis work was financially supported by a grant (403001123) from the Deputy of Research, Kerman University of Medical Sciences.
dc.identifier.doi10.1016/j.fbio.2025.108211
dc.identifier.issn2212-4292
dc.identifier.issn2212-4306
dc.identifier.scopus2-s2.0-105027385637
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.fbio.2025.108211
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34854
dc.identifier.volume75
dc.identifier.wosWOS:001658337000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofFood Bioscience
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectInterleukin
dc.subjectInflammation
dc.subjectCurcumin
dc.subjectInflammatory diseases
dc.subjectPathogenesis
dc.subjectCancer
dc.subjectCardiovascular diseases
dc.subjectKidney disorders
dc.subjectChronic inflammatory disease
dc.subjectNeurodegenerative disease
dc.titleCurcumin as a modulator of IL-18: A promising therapeutic approach for inflammatory diseases
dc.typeArticle

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