Evaluation of the Thalamic Region with Proton Magnetic Resonance Spectroscopy in Patients with Essential Tremor

Basit Öğe Kaydı
dc.authoridOztop Cakmak, Ozgur/0000-0003-3413-0332
dc.contributor.authorOzkan, Adile
dc.contributor.authorCandan, Fatma
dc.contributor.authorIsik, Nihal
dc.contributor.authorCanturk, Ilknur Aydin
dc.contributor.authorAri, Semra
dc.contributor.authorCakmak, Ozgur Oztop
dc.contributor.authorAyaz, Tunahan
dc.date.accessioned2025-01-27T21:00:07Z
dc.date.available2025-01-27T21:00:07Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Although essential tremor (ET) is the most common movement disorder, its pathogenesis is poorly understood. It is suggested that the ventral intermediate (VIM) nucleus of the thalamus is important in the pathophysiology disease. Materials and Methods: The present study aimed to evaluate N-acetylaspartate (NAA), choline (cho), and creatinine (Cr) values via proton magnetic resonance spectroscopy (H-1 MRS) of the VIM of the thalamus in 16 control patients and 42 patients with ET. Results: The mean NAA/Cr and NAA/Cho values of the thalamus VIM nucleus region in patients with ET was statistically significantly lower than the control group (p=0.001, p=0.005, respectively). In patients with ET, no significant relation was found between NAA/Cr, NAA/Cho values, and age, family history, disease duration, tremor severity, dominant extremity localization of tremor, and history of drug use (p>0.05). Conclusion: Low NAA values in the thalamus region of patients with ET indicate neuron loss and cell death. Neuron loss in the thalamus region has been suggested to play a part in the pathophysiology of the disease, and may indicate that ET is a neurodegenerative disease.
dc.identifier.doi10.4274/tnd.67044
dc.identifier.endpage158
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84959243076
dc.identifier.scopusqualityQ4
dc.identifier.startpage154
dc.identifier.urihttps://doi.org/10.4274/tnd.67044
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26944
dc.identifier.volume21
dc.identifier.wosWOS:000372008400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish Neurological Soc
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectEssential tremor
dc.subjectmagnetic resonance spectroscopy
dc.subjectthalamus
dc.titleEvaluation of the Thalamic Region with Proton Magnetic Resonance Spectroscopy in Patients with Essential Tremor
dc.title.alternativeEsansiyel Tremorlu Hastalarda Talamus Bölgesinin Proton Manyetik Rezonans Spektroskopi ile Değerlendirilmesi
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu