Comparison of Biomarkers in Blood and Urine According to Phenotypes in Chronic Obstructive Pulmonary Disease: Cross-Sectional Research

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dc.contributor.authorHünerel, Oylum
dc.contributor.authorMutlu, Pınar
dc.contributor.authorMirici, Nihal Arzu
dc.contributor.authorÇakir, Dilek Ülker
dc.contributor.authorTürkön, Hakan
dc.contributor.authorGül, Abdulhakim Hasan
dc.date.accessioned2025-01-27T19:02:27Z
dc.date.available2025-01-27T19:02:27Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide. Biomarkers have been recognized as an important tool in assessing COPD patients. In this study, we aimed to investigate the possible relationship between certain biomarkers and different COPD phenotypes. Material and Methods: Between January 1, 2017-December 31, 2017, a total of 85 patients who were admitted to the Çanakkale Onsekiz Mart University Faculty of Medicine Hospital Chest Diseases Outpatient Clinic with a diagnosis of COPD according to the Global Initiative for Chronic Obstructive Lung Disease 2017 Guidelines were included in this study. All patients filled in the COPD Assessment Test and modified Medical Research Council questionnaires. Patients were divided into 4 phenotypes: emphysema, chronic bronchitis, frequent exacerbation, and asthma COPD overlap syndrome (ACOS). Levels of C-reactive protein (CRP), desmosine, fibronectin, eotaxin, and interleukin (IL)-2 were measured and compared between the phenotypes. Results: The mean age was 64.56 years and 92.9% of the study population were males. Of 85 patients, 43 had emphysema, 13 had frequent exacerbation, 15 had chronic bronchitis, and 14 had ACOS phenotype. Blood fibronectin, eotaxin, and urine desmosine levels were significantly lower in patients with ACOS phenotype compared to the other phenotypes. In patients with the frequent exacerbation phenotype, the CRP level was significantly higher than that of the other three phenotypes. The IL-2 levels were similar in all phenotypes. Conclusion: Our study results suggest that these biomarkers may be useful in the differential diagnosis of COPD phenotypes. © 2022 by Türkiye Klinikleri.
dc.identifier.doi10.5336/medsci.2021-86396
dc.identifier.endpage190
dc.identifier.issn1300-0292
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85139511871
dc.identifier.scopusqualityQ4
dc.identifier.startpage183
dc.identifier.trdizinid1135098
dc.identifier.urihttps://doi.org/10.5336/medsci.2021-86396
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1135098
dc.identifier.urihttps://hdl.handle.net/20.500.12428/13498
dc.identifier.volume42
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkiye Klinikleri
dc.relation.ispartofTurkiye Klinikleri Journal of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250125
dc.subjectbiomarkers; chronic obstructive; phenotype; Pulmonary disease
dc.titleComparison of Biomarkers in Blood and Urine According to Phenotypes in Chronic Obstructive Pulmonary Disease: Cross-Sectional Research
dc.title.alternativeKronik Obstrüktif Akciğer Hastalığında Fenotiplere Göre Kanda ve İdrarda Biyobelirteçlerin Karşılaştırılması: Kesitsel Araştırma
dc.typeArticle

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