Superb ruthenium(ii) complex melody: Uncovering its hidden catalytic and biological properties

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dc.authoridDUMAN, Sibel/0000-0003-1517-9800
dc.authoridDERVISOGLU, Gokhan/0000-0001-7195-2031
dc.contributor.authorDuman, Sibel
dc.contributor.authorDervisoglu, Gokhan
dc.contributor.authorOzdemir, Fethi Ahmet
dc.contributor.authorSerbetci, Zafer
dc.contributor.authorErdener, Digdem
dc.contributor.authorDayan, Osman
dc.date.accessioned2025-01-27T20:54:15Z
dc.date.available2025-01-27T20:54:15Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAliphatic/aromatic nitrogen-substituted ligands have a very important role in ruthenium chemistry. Polydentate ligands with N-substituted pyridine rings are notable for their ability to easily modify the electronic and steric properties of ruthenium. In this study, the catalytic and biological activities of the [RuCl2(NNN)(CH3CN)] (NNN: 2,6-di(1H-pyrazol-3-yl)pyridine)) complex were examined for two different applications. Firstly, the superb Ru(II) complex was used to catalyze the methanolysis of NaBH4, and its initial rate was calculated as 69360 mLH(2)min(-1)g(cat)(-1). Secondly, the biological activities of the superb Ru(II) complex were examined. Accordingly, it was determined that this homogeneous complex showed anti-microbial activity on all bacteria used in the study, among the Gram-positive bacteria used in the study, the best result belongs to the Bacillus cereus EMC 19 bacterium with 8 mm, while among the Gram-negative bacteria, the best zone diameter belongs to the Pseudomonas aeruginosa DSM 50071 bacterium with 5 mm. However, it was observed that zone diameters varied between 8 mm and 3 mm. Compared to the control group, it was determined that 0.25 mg/mL concentration had 94.87%, 0.5 mg/mL concentration 96.10%, 1 mg/mL concentration 96.50%, and 2 mg/mL concentration 97.09% cytotoxic activity on the SH-SY5Y cell line. it was determined that all doses of the superb Ru(II) complex used in the study showed anti-cancer activity, but the anticancer activity shown at low doses was statistically more significant at the p < 0.05 level.
dc.description.sponsorshipTUBITAK (Scientific and Technical Research Council of Turkey) [107T808]
dc.description.sponsorshipO.D. acknowledges the support of TUBITAK (Scientific and Technical Research Council of Turkey) for project no. 107T808. S.D. thanks Assoc. Prof. Dr. Pinar ERTEN for her assistance during manual HGR measurements.
dc.identifier.doi10.1016/j.ijhydene.2024.06.425
dc.identifier.endpage96
dc.identifier.issn0360-3199
dc.identifier.issn1879-3487
dc.identifier.scopus2-s2.0-85197140276
dc.identifier.scopusqualityQ1
dc.identifier.startpage86
dc.identifier.urihttps://doi.org/10.1016/j.ijhydene.2024.06.425
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26022
dc.identifier.volume79
dc.identifier.wosWOS:001266933500001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofInternational Journal of Hydrogen Energy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectRuthenium complex
dc.subjectHomogeneous catalysis
dc.subjectSodium borohydride
dc.subjectMethanolysis
dc.subjectBiological activity
dc.titleSuperb ruthenium(ii) complex melody: Uncovering its hidden catalytic and biological properties
dc.typeArticle

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