Electrochemical behavior of formoterol fumarate and its determination in capsules for inhalation and human serum using differential-pulse and square-wave voltammetry

The electrochemical oxidation of formoterol fumarate (formoterol) has been carried out in aqueous solution in the pH range of 1.5-10.0 by cyclic, linear sweep, differential-pulse and square-wave voltammetry. The diffusion controlled nature of the waves was established. The mechanism of oxidation was discussed, Two voltammetric techniques for the determination of formoterol in 0.5 M sulfuric acid which allow quantitation over the 8 x 10 (6)-6 X 10 (-5) M range for both methods were proposed. Based on this study simple, rapid and selective two voltammetric methods were developed for the determination of formoterol in capsule dosage form and human serum.