Evaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis

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dc.authoridAsik, mehmet/0000-0002-0716-0221
dc.authoridsahin, sinan/0000-0002-3687-0580
dc.contributor.authorAsik, Mehmet
dc.contributor.authorSahin, Sinan
dc.contributor.authorOzkul, Faruk
dc.contributor.authorAnaforoglu, Inan
dc.contributor.authorAyhan, Semiha
dc.contributor.authorKaragol, Sukriye
dc.contributor.authorGunes, Fahri
dc.date.accessioned2025-01-27T20:39:20Z
dc.date.available2025-01-27T20:39:20Z
dc.date.issued2013
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective Hypothyroidism, whether overt or subclinical, has multiple effects on the cardiovascular system. Epicardial fat tissue (EFT) is closely related to cardiovascular disorders and atherosclerosis. Our study aimed to assess EFT thickness and carotid artery intima-media thickness (CIMT) in patients with Hashimoto's thyroiditis (HT) displaying overt and subclinical hypothyroidism (SCH). Design and patients The study included 33 patients with SCH and 24 patients with overt hypothyroidism (OH) with HT as well as 32 healthy controls. EFT thickness, CIMT, thyroid hormone levels and lipid parameters were measured in all subjects. Correlation analysis and linear regression analysis were performed for EFT thickness. Results Mean EFT thickness was 2.89 +/- 0.38, 3.53 +/- 0.92 and 4.56 +/- 1.61mm in control, SCH and OH groups, respectively (P < 0.001). EFT thickness of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). CIMT of OH patients was high compared with SCH and control subjects (P < 0.01 and < 0.001, respectively). In addition, EFT was significantly thicker in SCH patients than in controls (P < 0.05). Correlation analysis showed that EFT thickness was significantly positively correlated with CIMT, age, body mass index, systolic blood pressure, thyroid-stimulating hormone, total and LDL cholesterol and triglyceride and negatively correlated with free T4. In the regression analysis, EFT thickness retained its independent and positive association with CIMT, patient group (particularly OH) and systolic blood pressure. Conclusions Epicardial fat tissue thickness may be a useful indicator of early atherosclerosis in SCH and OH patients with HT.
dc.identifier.doi10.1111/cen.12176
dc.identifier.endpage576
dc.identifier.issn0300-0664
dc.identifier.issue4
dc.identifier.pmid23432641
dc.identifier.scopus2-s2.0-84883555319
dc.identifier.scopusqualityQ2
dc.identifier.startpage571
dc.identifier.urihttps://doi.org/10.1111/cen.12176
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23925
dc.identifier.volume79
dc.identifier.wosWOS:000323932200019
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Endocrinology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectIntima-Media Thickness
dc.subjectCoronary-Artery-Disease
dc.subjectIndependent Risk-Factor
dc.subjectSubclinical Hypothyroidism
dc.subjectAdipose-Tissue
dc.subjectMetabolic Syndrome
dc.subjectEuthyroid Subjects
dc.subjectCarotid-Artery
dc.subjectHeart-Disease
dc.subjectAtherosclerosis
dc.titleEvaluation of epicardial fat tissue thickness in patients with Hashimoto thyroiditis
dc.typeArticle

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