Synthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules

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dc.authoridPARALI, Tezcan/0000-0001-7263-3139
dc.authoridSenel, Mehmet/0000-0001-7366-4746
dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridDizman, Cemil/0000-0002-1780-3008
dc.contributor.authorTulu, Metin
dc.contributor.authorAghatabay, Naz M.
dc.contributor.authorSenel, Mehmet
dc.contributor.authorDizman, Cemil
dc.contributor.authorParali, Tezcan
dc.contributor.authorDulger, Basaran
dc.date.accessioned2025-01-27T20:52:06Z
dc.date.available2025-01-27T20:52:06Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractSeveral families of water soluble dendrimers were synthesized based on poly (propyleneoxide) amines (Jeffamines (R)) (PI). PI-core and branched units were constructed from both methylacrylate and ethylenediamine (P-2-P-9, and generations 0-3 with - NH2, - COOH functionalities). They were characterized by elemental analysis (HA), gel permeation chromatography (GPC) , FT-IR, H-1, and C-13 NMR. The antimicrobial activities of only water soluble compounds (P-1, P-3, P-4, P-6, P-7 and P-9) were evaluated using disk diffusion method in water as well as the minimal inhibitory concentration (MIC) dilution method against 9 bacteria. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of Penicillin-g, Ampicillin, Cefotaxime, Vancomycin, Oflaxacin, and Tetracyclin, well-known antibacterial agents. The results from dilution procedure are compared with Gentamycin as antibacterial and Nystatin as antifungal. The antifungal activities are reported on five yeast cultures namely, Candida albicans, Kluyveromyces fragilis, Rhodotorula rubra, Debaryomyces hansenii, and Hanseniaspora guilliermondii, and the results are referenced with Nystatin, Ketaconazole, and Clotrimazole, commercial antifungal agents. In most cases, the compounds show broad-spectrum (Gram-positive and Gram-negative bacteria) activities that are comparatively higher or equipotent to the antibiotic and antifungall agents in the comparison tests. (C) 2008 Elsevier Masson SAS. All rights reserved.
dc.description.sponsorshipFatih University Scientific Research Centre [P50020603, P50020703]; Turkish Prime Ministry State Planning Organization (DPT)
dc.description.sponsorshipWe would like to extend our gratitude to the Fatih University Scientific Research Centre for their financial support under Projects (P50020603 and P50020703) and Turkish Prime Ministry State Planning Organization (DPT).
dc.identifier.doi10.1016/j.ejmech.2008.06.016
dc.identifier.endpage1099
dc.identifier.issn0223-5234
dc.identifier.issn1768-3254
dc.identifier.issue3
dc.identifier.pmid18657884
dc.identifier.scopus2-s2.0-60549095163
dc.identifier.scopusqualityQ1
dc.identifier.startpage1093
dc.identifier.urihttps://doi.org/10.1016/j.ejmech.2008.06.016
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25660
dc.identifier.volume44
dc.identifier.wosWOS:000264558600018
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier France-Editions Scientifiques Medicales Elsevier
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAntibacterial
dc.subjectDendritic Jeffamines
dc.subjectMichael addition
dc.subjectNystatin
dc.subjectPAMAM
dc.titleSynthesis, characterization and antimicrobial activity of water soluble dendritic macromolecules
dc.typeArticle

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