Vascular endothelial functions, carotid intima-media thickness, and soluble CD40 ligand levels in dipper and nondipper essential hypertensive patients

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dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.authoridErcan, Ertugrul/0000-0003-0480-4738
dc.contributor.authorAlioglu, Emin
dc.contributor.authorTurk, Ugur O.
dc.contributor.authorBicak, Firat
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorAtila, Dincer
dc.contributor.authorBarisik, Vatan
dc.contributor.authorErcan, Ertugrul
dc.date.accessioned2025-01-27T20:12:16Z
dc.date.available2025-01-27T20:12:16Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description15th Meeting of the Italian-National-Society-of-Endocrinology -- OCT 13-15, 2005 -- Cagliari, ITALY
dc.description.abstractObjective The lack of nocturnal decline in blood pressure (BP) is associated with an increase in cardiovascular events. Soluble CD40 ligand (sCD40L) is involved in the pathogenesis of risk factor-related vascular damage. The purpose of this study was to examine the relationship between vascular endothelial functions, carotid intimamedia thickness (cIMT), plasma sCD40L levels and circadian BP profile in patients with essential hypertension. Material and methods The study population consisted of 81 essential hypertensive out-patients. BP dipping was defined as a night-to-day systolic and diastolic decrease >= 10%. Forty-seven dipper and 34 nondipper patients were compared. High sensitivity C-reactive protein (hs-CRP), sCD40L and urinary albumin were measured. Brachial artery flow-mediated dilatation (FMD) and cIMT was compared between the groups. Results sCD40L level (3.28 +/- 2.08 and 2.30 +/- 1.99 ng/ml, respectively, P = 0.036) and urinary albumin concentration (36.7 +/- 20.1 and 23 +/- 29.7 mg/l, respectively, P < 0.0001) were higher in nondippers than in dippers. Serum hs-CRP levels were not significantly different. FMD was found higher in dippers than nondippers (11.8 +/- 3.9% and 6.6 +/- 2.2%, respectively, P < 0.0001). The average cIMT was significantly higher in nondippers than dippers (0.928 +/- 0.060 Vs. 0.734 +/- 0.134 mm; P < 0.0001). Conclusions Nondipper patern has an additional negative effect on endothelial functions in hypertensive patients. Nondippers have enhanced sCD40L levels, which may contribute to their increased susceptibility to develop vascular damage.
dc.description.sponsorshipItalian Nat Soc Endocrinol,Minist Educ,Univ & Res Italy
dc.identifier.doi10.1007/s00392-008-0654-9
dc.identifier.endpage462
dc.identifier.issn1861-0684
dc.identifier.issn1861-0692
dc.identifier.issue7
dc.identifier.pmid18347767
dc.identifier.scopus2-s2.0-47549097779
dc.identifier.scopusqualityQ1
dc.identifier.startpage457
dc.identifier.urihttps://doi.org/10.1007/s00392-008-0654-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20896
dc.identifier.volume97
dc.identifier.wosWOS:000257629300006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofClinical Research in Cardiology
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCD40 ligand
dc.subjecthypertension
dc.subjectendothelial functions
dc.subjectcarotid intima-media thickness
dc.subjectflow mediated dilatation
dc.titleVascular endothelial functions, carotid intima-media thickness, and soluble CD40 ligand levels in dipper and nondipper essential hypertensive patients
dc.typeConference Object

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