Protective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney

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dc.authoridAlan, Cabir/0000-0002-6024-4475
dc.contributor.authorAlan, Cabir
dc.contributor.authorKocoglu, Hasan
dc.contributor.authorAltintas, Ramazan
dc.contributor.authorAlici, Bulent
dc.contributor.authorErsay, Ahmet Resit
dc.date.accessioned2025-01-27T20:34:46Z
dc.date.available2025-01-27T20:34:46Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction: Transforming growth factor-beta 1 (TGF-beta 1) has a crucial role in collagen synthesis and fibrosis. TGF-beta 1 can be antagonized and/or reduced by the action of certain agents. We propose to identify the role of decorin in treatment of tubular and interstitial fibrosis and in the inhibition of TGF-beta 1 in an acute ischaemic kidney. Material and methods: We grouped 34 female Sprague Dawley type rats into 3 groups as 9 sham, 9 ischaemia-reperfusion (I/R) and 16 I/R + decorin respectively. The rats in the I/R + decorin group had decorin administered intraperitoneally at the dose of 0.1 mg/kg for 9 days after reperfusion. After 9 days, all the rats in the 3 groups were unilaterally nephrectomized. The TGF-beta 1 level was measured immunohistochemically in the nephrectomized material. Results: The TGF-beta 1 level was lower in the I/R + decorin group. Evaluation of apoptotic activity level by caspase staining showed a statistically significant difference between the 3 groups. The number of caspase stained cells was lower in the I/R + decorin group. The amount of collagen in interstitial tissue was higher in the I/R group than in the I/R + decorin group, but this difference was not statistically significant. Conclusions: We found that the TOE-Ill level the so-called initiator of fibrotic activity and apoptotic activity were low in the I/R + decorin group. Additional studies must be performed to understand the role of decorin in inhibition of TGF-beta 1 and to assess decorin's routine use in acute renal ischaemia.
dc.identifier.doi10.5114/aoms.2011.22069
dc.identifier.endpage216
dc.identifier.issn1734-1922
dc.identifier.issn1896-9151
dc.identifier.issue2
dc.identifier.pmid22291758
dc.identifier.scopus2-s2.0-79956353613
dc.identifier.scopusqualityQ1
dc.identifier.startpage211
dc.identifier.urihttps://doi.org/10.5114/aoms.2011.22069
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23457
dc.identifier.volume7
dc.identifier.wosWOS:000290915100004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofArchives of Medical Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecttransforming growth factor-beta 1
dc.subjectdecorin
dc.subjectglomerulosclerosis
dc.titleProtective effect of decorin on acute ischaemia-reperfusion injury in the rat kidney
dc.typeArticle

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