Short aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients

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dc.authoridASLAN, ADEM/0000-0001-9432-5399
dc.contributor.authorEser, O.
dc.contributor.authorEser, B.
dc.contributor.authorCosar, M.
dc.contributor.authorErdogan, M. O.
dc.contributor.authorAslan, A.
dc.contributor.authorYildiz, H.
dc.contributor.authorSolak, M.
dc.date.accessioned2025-01-27T20:43:41Z
dc.date.available2025-01-27T20:43:41Z
dc.date.issued2011
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractWe investigated a possible association between aggrecan gene polymorphism and lumbar degenerative disc disease in Turkish patients. One hundred 20-30-year-old patients with or without low back pain were selected for the study. Lumbar magnetic resonance imaging was performed on all patients. The patient group had low back pain clinically and degenerative disc disease radiographically. The control group included patients with and without low back pain: all were negative radiographically for degenerative disc disease. Genomic DNA was extracted from all participants. A PCR assay were used to evaluate variable number of tandem repeat polymorphism of aggrecan gene alleles to determine if there was any correlation with degenerative disc disease. Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. A significant association was also found between short repeated alleles of the aggrecan gene and multilevel disc herniation as well as extrusion and sequestration types of disc herniation. In Turkish population, short repeated alleles of the aggrecan gene are associated with increased disc degeneration and disc herniation.
dc.description.sponsorshipKocatepe University Scientific Research Committee [051.TIP.44]
dc.description.sponsorshipThe authors thank Murat Acar and Bumin Degirmenci for help with visual assessment of magnetic resonance images. Research supported by the Kocatepe University Scientific Research Committee (Project #051.TIP.44).
dc.identifier.doi10.4238/vol10-3gmr1222
dc.identifier.endpage1930
dc.identifier.issn1676-5680
dc.identifier.issue3
dc.identifier.pmid21948754
dc.identifier.scopus2-s2.0-80955141264
dc.identifier.scopusqualityQ4
dc.identifier.startpage1923
dc.identifier.urihttps://doi.org/10.4238/vol10-3gmr1222
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24328
dc.identifier.volume10
dc.identifier.wosWOS:000295823500062
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFunpec-Editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAggrecan gene
dc.subjectDisc degeneration
dc.subjectPolymorphism
dc.subjectLumbar
dc.titleShort aggrecan gene repetitive alleles associated with lumbar degenerative disc disease in Turkish patients
dc.typeArticle

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