Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging

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dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.contributor.authorResorlu, Hatice
dc.contributor.authorResorlu, Mustafa
dc.contributor.authorGokmen, Ferhat
dc.contributor.authorAkbal, Ayla
dc.contributor.authorAdam, Gurhan
dc.contributor.authorKomurcu, Erkam
dc.contributor.authorGoksel, Ferdi
dc.date.accessioned2025-01-27T20:52:21Z
dc.date.available2025-01-27T20:52:21Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstract[Purpose] The aim this study was to assess the relation between bone mineral density (BMD) and mean platelet volume (MPV) in ankylosing spondylitis (AS) patients, and evaluate the diagnostic role of the diffusion-weighted magnetic resonance imaging (MRI). [Subjects and Methods] Fifty patients diagnosed with AS were divided into two groups on the basis of BMD, a normal group (n=30) and an osteopenic (n=20) group. [Results] Duration of disease in the group with a normal BMD was 10.3 +/- 7.0 years, while it was 16.7 +/- 12.2 years in the osteopenia group. MPV was high in the osteopenia group, while no significant differences were observed between the groups in terms of apparent diffusion coefficient (ADC) and platelet distribution width (PDW). There was a positive correlation between MPV and duration of disease. Correlations between ADC value and the lumbar T score, femoral neck T score, and duration of disease were insignificant. A negative correlation was observed between BMD and disease duration. [Conclusion] Diffusion-weighted imaging provides valuable results in osteoporosis but is not a suitable technique for evaluating BMD in patients with AS because of the local and systemic inflammatory effects in the musculoskeletal system. The common pathophysiology of atherosclerosis and osteoporosis plays an important role in the negative correlation observed between MPV and BMD in patients with AS.
dc.identifier.doi10.1589/jpts.27.1137
dc.identifier.endpage1140
dc.identifier.issn0915-5287
dc.identifier.issn2187-5626
dc.identifier.issue4
dc.identifier.pmid25995574
dc.identifier.scopus2-s2.0-84928777054
dc.identifier.scopusqualityN/A
dc.identifier.startpage1137
dc.identifier.urihttps://doi.org/10.1589/jpts.27.1137
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25739
dc.identifier.volume27
dc.identifier.wosWOS:000354780200038
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSoc Physical Therapy Science
dc.relation.ispartofJournal of Physical Therapy Science
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAnkylosing spondylitis
dc.subjectBone mineral density
dc.subjectMean platelet volume
dc.titleAssociation between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging
dc.typeArticle

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