Multimodal characterization of newly synthesized Schiff base PEI CA/ N-GQDs nanomaterial and its anticancer effects on human neuroblastoma cells

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dc.authorid0000-0002-1377-2021
dc.authorid0000-0001-7298-6225
dc.authorid0000-0003-0219-3312
dc.authorid0000-0003-3757-3622
dc.contributor.authorKilic, Murat
dc.contributor.authorGunes, Buket Altinok
dc.contributor.authorKirlangic, Omer Faruk
dc.contributor.authorKetenoglu, Didem
dc.contributor.authorKirlangic, Fatma Zeynep
dc.contributor.authorElci, Pinar Mualla
dc.contributor.authorAslan, Aysenur
dc.date.accessioned2026-02-03T12:02:40Z
dc.date.available2026-02-03T12:02:40Z
dc.date.issued2026
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we synthesized a new material, Schiff base PEI-CA/N-GQDs, from the reaction of 4-hydroxy-3-methoxy-cinnamaldehyde (CA) with polyethyleneimine-functionalized N-doped graphene quantum dots (PEI N-GQDs). The synthesized material was experimentally characterized by FT-IR, UV-Vis, SEM, EDX, AFM, XRD, and TGA, as well as theoretically by the DFT method. In addition to their biological activities, their cytotoxic, apoptotic, and cell cycle-arresting effects were investigated in human epithelial neuroblastoma (SH-SY5Y) cells. According to the UV-Vis data, we observed that the material exhibits phenol-imine/keto-amine tautomerism, a phenomenon common in 2-hydroxy Schiff bases that helps to explain the various properties of the material. Furthermore, this material predominantly exists in the keto-amine form. The material demonstrated favorable electron transfer properties, making it suitable for electrochemical applications. We showed that it binds to DNA through an electrostatic interaction and causes oxidative and hydrolytic cleavage in DNA, which results in an increase in ROS in the cell, an activation of the CASPASE-3, leading the cells to undergo apoptosis, and inhibiting cell division in the G1/S phase. We believe that the chemical properties of the Schiff-based PEI N-GQDs make them a superior carrier molecule for cancer treatment. Furthermore, the anticancer properties of the Schiff-based PEI-CA/N-GQDs suggest their potential as a therapeutic agent for neuroblastoma.
dc.description.sponsorshipAnkara University Scientific Research Projects Coordination Unit [FBA-2024-3174]
dc.description.sponsorshipThis work has been supported by Ankara University Scientific Research Projects Coordination Unit under grant number: FBA-2024-3174. The numerical calculations reported in this paper were fully performed at TUBITAK ULAKBIM, High Performance and Grid Computing Center (TRUBA resources) .
dc.identifier.doi10.1016/j.molstruc.2025.143744
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-105014106601
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2025.143744
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34814
dc.identifier.volume1349
dc.identifier.wosWOS:001562786700008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectConiferaldehyde (CA)
dc.subjectSchiff base
dc.subjectPEI N-GQDs
dc.subjectApoptosis
dc.subjectNeuroblastoma
dc.titleMultimodal characterization of newly synthesized Schiff base PEI CA/ N-GQDs nanomaterial and its anticancer effects on human neuroblastoma cells
dc.typeArticle

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