The protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats

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dc.authoridHanci, Volkan/0000-0002-2227-194X
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.contributor.authorGencer, Baran
dc.contributor.authorKaraca, Turan
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorKara, Selcuk
dc.contributor.authorArikan, Sedat
dc.contributor.authorToman, Huseyin
dc.contributor.authorKaraboga, Ihsan
dc.date.accessioned2025-01-27T20:41:03Z
dc.date.available2025-01-27T20:41:03Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: Dexmedetomidine is an alpha 2 adrenoceptor agonist and can be used for postoperative sedation, analgesia and anesthesia-sparing properties. Furthermore, the neuroprotective effects against ischemia/reperfusion (I/R) injury in the central nervous system have been shown in experimental studies. This study aimed to investigate the protective effects of dexmedetomidine against apoptosis in retinal I/R injury in the rat. Materials and methods: Retinal I/R injury was induced by transient elevation of intraocular pressure. Eighteen animals were divided into three groups (n = 6): sham, I/R and treatment. The I/R injury and protective effects of the dexmedetomidine were evaluated by retinal thickness determined by histological sections, terminal deoxynucleotidyl transferase-mediated biotin-deoxyuridine triphosphate nick-end labeling (TUNEL) and immunohistochemistry of caspases 3. Results: A decrease in the retinal thickness and an increase in the apoptotic cells were found to be statistically significant in I/R and treatment groups when compared with the control group. However, in comparison with the I/R group we realized that the administration of dexmedetomidine reduced the thinning of retinal thickness and also decreased the number of caspases 3 and TUNEL-positive cells. Conclusion: Dexmedetomidine is protective against apoptosis in retinal I/R injury in rats.
dc.identifier.doi10.3109/15569527.2013.857677
dc.identifier.endpage288
dc.identifier.issn1556-9527
dc.identifier.issn1556-9535
dc.identifier.issue4
dc.identifier.pmid24517497
dc.identifier.scopus2-s2.0-84912101780
dc.identifier.scopusqualityQ3
dc.identifier.startpage283
dc.identifier.urihttps://doi.org/10.3109/15569527.2013.857677
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23988
dc.identifier.volume33
dc.identifier.wosWOS:000345498400004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofCutaneous and Ocular Toxicology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectApoptosis
dc.subjectdexmedetomidine
dc.subjectretinal ischemia/reperfusion injury
dc.titleThe protective effects of dexmedetomidine against apoptosis in retinal ischemia/reperfusion injury in rats
dc.typeArticle

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