Comparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh: Real-World Data

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dc.authorid0000-0003-1944-2477en_US
dc.authorscopusid57926207600en_US
dc.authorwosidABH-8663-2020en_US
dc.contributor.authorSarıgül Yıldırım, Figen
dc.contributor.authorCandevir, Aslıhan
dc.contributor.authorAkhan, Sıla
dc.contributor.authorKaya, Selçuk
dc.contributor.authorÇabalak, Mehmet
dc.contributor.authorAlkan, Sevil
dc.date.accessioned2024-01-25T07:17:29Z
dc.date.available2024-01-25T07:17:29Z
dc.date.issued2023en_US
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü
dc.description.abstractBackground: Rapid initiation of antiretroviral therapy (ART) reduces the transmission of HIV infection in the community. This study aimed to determine whether rapid ART initiation is effective compared to standard ART treatment in our country. Methods: Patients were grouped based on time to treatment initiation. HIV RNA levels, CD+4 T cell count, CD4/CD8 ratio, and ART regimens were recorded at baseline and follow-up visits for 12 months. Results: There were 368-ART naive adults (treatment initiated at the time of HIV diagnosis; 143 on the first day, 48 on the secondseventh day, and 177 after the seventh day). Although virological suppression rates at 12th months were higher in all groups, over 90% on average, there were no statistically significant differences in HIV-1 RNA suppression rates, CD+4 T cell count, and CD4/CD8 ratio normalization in the studied months but in multivariate logistic regression analysis; showed a significant correlation between both virological and immunological response and those with CD4+ T <350 cells/mL at 12th month in total patients. Conclusion: Our findings support the broader application of recommendations for rapid ART initiation in HIV patients.en_US
dc.identifier.citationYıldırım, F. S., Candevir, A., Akhan, S., Kaya, S., Çabalak, M., Ersöz, G., … Çelen, M. K. (2023). Rapid initiation of antiretroviral therapy. International Journal of General Medicine, 16, 1867–1877. https://doi.org/10.2147/IJGM.S393370en_US
dc.identifier.doi10.2147/IJGM.S393370
dc.identifier.endpage1877en_US
dc.identifier.issn1178-7074
dc.identifier.pmid37213471
dc.identifier.scopus2-s2.0-85160296181
dc.identifier.startpage1867en_US
dc.identifier.urihttps://doi.org/10.2147/IJGM.S393370
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5420
dc.identifier.volume16en_US
dc.identifier.wosWOS:000994365300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlkan, Sevil
dc.language.isoen
dc.publisherDove Medical Press Ltden_US
dc.relation.ispartofInternational Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectAntiretroviralen_US
dc.subjectARTen_US
dc.subjectHIVen_US
dc.subjectRapid starten_US
dc.titleComparison of Immunological and Virological Recovery with Rapid, Early, and Late Start of Antiretroviral Treatment in Naive Plwh: Real-World Data
dc.typeArticle

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