Effect of vitamin E on kidney histomorphology in rats exposed to bisphenol A

Purpose: The aim of this study was to determine the effects of vitamin E on renal histomorphology in rats exposed to bisphenol A (BPA). Materials and Methods: The rats were randomly divided into four groups as sham, vitamin E, BPA and vitamin E+BPA. The applications of vitamin E and BPA were continued for three weeks. Crossman's triple staining method was applied to the sections obtained from kidney tissues for histomorphological examinations at the end of the experiment. Also, superoxide dismutase (SOD) activity and malondialdehyde (MDA) level were measured in kidney tissue. Results: The number of corpusculum renis, diameters of proximal tubule, distal tubule, ascending limb of Henle's loop and collecting duct as well as SOD activity significantly decreased in BPA group compared to sham group. Also, the number of corpusculum renis, diameters of ascending limb of Henle's loop and collecting duct as well as SOD activity significantly increased in vitamin E+BPA group compared to BPA group. On the other hand, MDA level significantly increased in BPA group compared to sham group and it significantly decreased in vitamin E+BPA group compared to BPA group. Conclusion: BPA may cause histomorphological and oxidative changes in the kidney. In addition, vitamin E may contribute to the preservation of renal tissue by reducing oxidative damage in BPA exposure.