The Effects of Hyperbaric Oxygen at Different Pressures on Oxidative Stress and Antioxidant Status in Rats

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dc.authoridKorpinar, Sefika/0000-0002-8155-3867
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.contributor.authorKorpinar, Sefika
dc.contributor.authorUzun, Hafize
dc.date.accessioned2025-01-27T20:26:51Z
dc.date.available2025-01-27T20:26:51Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: The optimal use of oxygen at greater than atmospheric pressures in any operational or therapeutic application (hyperbaric oxygen, HBO2) requires awareness of the fact that the beneficial effects of oxygen coexist with toxic effects depending on the pressure and duration of exposure. In this study, we aimed to investigate the effect of HBO2 therapy on oxidative stress and antioxidant status in commonly used protocol for acute HBO2 indications, such as carbon monoxide intoxication, central retinal artery occlusion, crush injury, gas gangrene, and to compare it with normobaric oxygen (NBO2) in healthy rats. Materials and Methods: Fifty-six male, young adult Wistar albino rats were randomly divided into seven groups and named as Group I through Group VII. Plasma malondialdehyde (MDA), superoxide dismutase (SOD), and erythrocyte glutathione (GSH) levels in control group were compared to the levels in other groups. Results: The increases in MDA levels and the decrease in SOD activities were statistically significant in HBO2 groups at the end of the first 24 h when compared to the control group, and the significant decrease in erythrocyte GSH level was only at 2.4 atmospheres absolute. Conclusions: The present study showed that pressure and frequency of exposure are important factors to consider when investigating HBO2-induced oxidative stress and antioxidant response.
dc.identifier.doi10.3390/medicina55050205
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue5
dc.identifier.pmid31137620
dc.identifier.scopus2-s2.0-85067305590
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina55050205
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22462
dc.identifier.volume55
dc.identifier.wosWOS:000472666200090
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjecthyperbaric oxygen
dc.subjectmalondialdehyde
dc.subjectsuperoxide dismutase
dc.subjectglutathione
dc.titleThe Effects of Hyperbaric Oxygen at Different Pressures on Oxidative Stress and Antioxidant Status in Rats
dc.typeArticle

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