Genistein Exerts Neuroprotective Effect on Focal Cerebral Ischemia Injury in Rats

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dc.authoridAras, Adem Bozkurt/0000-0002-0140-5224
dc.authoridguven, mustafa/0000-0001-8643-9775
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.contributor.authorAras, Adem Bozkurt
dc.contributor.authorGuven, Mustafa
dc.contributor.authorAkman, Tarik
dc.contributor.authorAlacam, Hasan
dc.contributor.authorKalkan, Yildiray
dc.contributor.authorSılan, Coşkun
dc.contributor.authorCosar, Murat
dc.date.accessioned2025-01-27T21:00:07Z
dc.date.available2025-01-27T21:00:07Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBrain ischemia and treatment are one of the important topics in neurological science. Free oxygen radicals and inflammation formed after ischemia are accepted as the most important causes of damage. Currently, there are studies on many chemopreventive agents to prevent cerebral ischemia damage. Our aim is to research the preventive effect of the active ingredient in genistein, previously unstudied, on oxidative damage in cerebral ischemia. Rats were randomly divided into three groups: control group (no medication or surgical procedure), ischemia group, and artery ischemia+genistein group, sacrificed at 24 h after ischemia. The harvested brain tissue from the right hemisphere was investigated histopathologically and for tissue biochemistry. Superoxide dismutase and nuclear respiratory factor 1 values decreased after ischemia and they increased after genistein treatment, while increased malondialdehyde levels after ischemia reduced after treatment. Apoptosis-related cysteine peptidase caspase-3 and caspase-9 values increased after ischemia, but reduced after treatment. Our study revealed that genistein treatment in cerebral ischemia reduced oxidative stress and neuronal degeneration. We believe that genistein treatment may be an alternative treatment method.
dc.identifier.doi10.1007/s10753-014-0102-0
dc.identifier.endpage1321
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue3
dc.identifier.pmid25567369
dc.identifier.scopus2-s2.0-84939980075
dc.identifier.scopusqualityQ1
dc.identifier.startpage1311
dc.identifier.urihttps://doi.org/10.1007/s10753-014-0102-0
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26942
dc.identifier.volume38
dc.identifier.wosWOS:000354086100043
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectbrain ischemia
dc.subjectgenistein
dc.subjectrats
dc.subjectoxidative stress
dc.subjectapoptosis
dc.subjectmalondialdehyde
dc.subjectnuclear respiratory factor 1
dc.titleGenistein Exerts Neuroprotective Effect on Focal Cerebral Ischemia Injury in Rats
dc.typeArticle

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