Nanoencapsulation of Origanum vulgare essential oil into liposomes with anticancer potential

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dc.authoridbagci, ufuk/0000-0002-1511-2465
dc.authoridKryeziu, Toske/0000-0002-5591-2520
dc.authoridLoshaj-Shala, Aida/0000-0003-2640-4356
dc.contributor.authorKryeziu, T. L.
dc.contributor.authorHaloci, E.
dc.contributor.authorLoshaj-Shala, A.
dc.contributor.authorBagci, U.
dc.contributor.authorOral, A.
dc.contributor.authorStefkov, G. J.
dc.contributor.authorZimmer, A.
dc.date.accessioned2025-01-27T20:14:20Z
dc.date.available2025-01-27T20:14:20Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractOriganum vulgare L. essential oil possesses a wide spectrum of biological activities. Nanoencapsulation of O. vulgare essential oil into liposomes seems to be a promising strategy to maintain and improve these biological properties. This research was carried out to develop a suitable liposomal formulation for the effective encapsulation of O. vulgare essential oil in order to improve the antioxidant and cytotoxic activities. The characterization of liposomal nanocarriers was conducted in terms of size, zeta potential, and encapsulation efficiency. An MTT assay was used to assess the cytotoxic activity of the prepared and characterized O. vulgare essential oil liposomes in MCF-7 cancer cell lines. Antioxidant activity was determined by assessing DPPH scavenging activity. O. vulgare essential oil exerted cytotoxic activity with an IC50 of 50 ??g/ml. The essential oil of O. vulgare was effectively encapsulated in liposomes, with no significant change observed among the formulations. The antioxidant activity was significantly enhanced after encapsulating the essential oil in liposomes. Origanum vulgare essential-oil-loaded Phospholipon 90H liposomes demonstrated considerably increased cytotoxic activity against MCF-7 cells, whereas Lipoid S100 liposomes showed no significant differences from the non-encapsulated essential oil. Phospholipon 85G liposomes had the least cytotoxic impact. As a result, liposomes containing O. vulgare essential oil may be promising nanocarriers for the development of anticancer agents.
dc.description.sponsorshipKosovo Ministry of Education, Science, Technology and Innovation [2-1881-2-7]
dc.description.sponsorshipAcknowledgments: The authors are grateful to the Kosovo Ministry of Education, Science, Technology and Innovation for financial support by providing a research grant (No. 2-1881-2-7) .
dc.identifier.doi10.1691/ph.2022.1230
dc.identifier.endpage178
dc.identifier.issn0031-7144
dc.identifier.issue6
dc.identifier.pmid35751165
dc.identifier.scopus2-s2.0-85133102333
dc.identifier.scopusqualityQ3
dc.identifier.startpage172
dc.identifier.urihttps://doi.org/10.1691/ph.2022.1230
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21054
dc.identifier.volume77
dc.identifier.wosWOS:000823311800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAvoxa-Mediengruppe Deutscher Apotheker Gmbh
dc.relation.ispartofPharmazie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAntioxidant
dc.subjectAgents
dc.titleNanoencapsulation of Origanum vulgare essential oil into liposomes with anticancer potential
dc.typeArticle

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