Synthesis, Characterization and Biomedical Applications of p(HEMA-co-APTMACI) Hydrogels Crosslinked with Modified Silica Nanoparticles

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dc.contributor.authorYilmaz, Betul
dc.contributor.authorÖzay, Özgür
dc.date.accessioned2025-01-27T20:26:57Z
dc.date.available2025-01-27T20:26:57Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, a new silica-based crosslinker was successfully synthesized with the reaction between silica nanoparticles modified with amino groups and glycidyl methacrylate (GMA). Using the synthesized silica-based crosslinker, p(HEMA) and p(HEMA-co-APTMACI) hydrogels were synthesized for use as drug carrier systems with the free radical polymerization method. The synthesized silica-based crosslinker and hydrogels were characterized using scanning electron microscopy (SEM) and Fourier transform-infrared spectroscopy (FTIR) devices. The swelling behavior of hydrogels cross-linked with silica was investigated in different physiological media. The hydrogels were loaded with sodium diclofenac (NaDc) as a model drug. Drug release studies from the obtained drug-loaded hydrogels were performed at 37 degrees C in PBS (pH 7.0) media. Additionally, the antibacterial properties of the hydrogels synthesized in the study were investigated against E. coli (gram-negative), B. subtilis, and S. aureus (gram-positive) bacteria using the disk diffusion method. At the end of the study, p(HEMA-co-APTMACI) hydrogels were determined to display a better drug release profile than p(HEMA) hydrogels.
dc.description.sponsorshipCanakkale Onsekiz Mart University [FYL-2019-3106]
dc.description.sponsorshipThis research was funded by the Canakkale Onsekiz Mart University [FYL-2019-3106] .
dc.identifier.doi10.33263/BRIAC123.36643680
dc.identifier.endpage3680
dc.identifier.issn2069-5837
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85112370737
dc.identifier.scopusqualityQ2
dc.identifier.startpage3664
dc.identifier.urihttps://doi.org/10.33263/BRIAC123.36643680
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22514
dc.identifier.volume12
dc.identifier.wosWOS:000686904100064
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBiointerface Research Applied Chemistry
dc.relation.ispartofBiointerface Research in Applied Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subject(3-acrylamidopropyl) trimethylammonium chloride
dc.subject2-hydroxyethyl methacrylate
dc.subjectsilica-based crosslinker
dc.subjectdrug release
dc.subjecthydrogel
dc.titleSynthesis, Characterization and Biomedical Applications of p(HEMA-co-APTMACI) Hydrogels Crosslinked with Modified Silica Nanoparticles
dc.typeArticle

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