Effects of Acute Pancreatitis on Plasma Total and Lipid Bound Sialic Acid Levels: An Experimental Study in Rats

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dc.contributor.authorOzkan, O. F.
dc.contributor.authorCikman, O.
dc.contributor.authorRoach, C.
dc.contributor.authorKemik, A. S.
dc.contributor.authorGunes, F.
dc.contributor.authorKaraayvaz, M.
dc.date.accessioned2025-01-27T20:43:58Z
dc.date.available2025-01-27T20:43:58Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: We investigated the relationship between serum levels of total sialic acid, lipid bound sialic acid and acute pancreatitis in a rat model of a common bile duct ligation induced acute pancreatitis. Methods: Twenty five Sprague-Dawley male rats weighing 250-300g were divided into two groups (n=10: control, n=15: experimental). In the control group only a sham laparotomy was performed. In the experimental group, acute pancreatitis was induced by common pancreatobiliary tract ligation. After 36 hours the rats were killed and amylase, serum total sialic acid, lipid bound sialic acid and lipid profiles were measured. Histopathological confirmation of acute pancreatitis was done using hematoxylin and eosin staining. Results: Mean amylase, total sialic acid (TSA) and lipid bound sialic acid (LBSA) measurements in the experimental group were significantly higher than in the control group. There was no significant difference in the lipid profiles between the two groups. Conclusion: Increased levels of TSA and LBSA can be useful as specific markers in the diagnosis of acute pancreatitis independent of serum lipid profile.
dc.identifier.endpage492
dc.identifier.issn1221-9118
dc.identifier.issn1842-368X
dc.identifier.issue4
dc.identifier.pmid25149611
dc.identifier.scopus2-s2.0-84906819947
dc.identifier.scopusqualityQ3
dc.identifier.startpage486
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24437
dc.identifier.volume109
dc.identifier.wosWOS:000492689400009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherEditura Celsius
dc.relation.ispartofChirurgia
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAcute pancreatitis
dc.subjecttotal sialic acid
dc.subjectlipid bounded sialic acid
dc.subjectlipid profile
dc.subjectexperimental study
dc.titleEffects of Acute Pancreatitis on Plasma Total and Lipid Bound Sialic Acid Levels: An Experimental Study in Rats
dc.typeArticle

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