Melatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats

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dc.authoridDemir, Ufuk/0000-0002-0020-1633
dc.authoriduzun, metehan/0000-0003-1406-5473
dc.contributor.authorDoganlar, Oguzhan
dc.contributor.authorDoganlar, Zeynep Banu
dc.contributor.authorOvali, Mehmet Akif
dc.contributor.authorGuclu, Orkut
dc.contributor.authorDemir, Ufuk
dc.contributor.authorDogan, Ayten
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:54:27Z
dc.date.available2025-01-27T20:54:27Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective This study aimed to investigate the effects of melatonin on cardiac oxidative stress and apoptosis in the fetal heart in RUPP rats. Methods The fetal heart samples were obtained from melatonin administrated RUPP rats Results Our results indicate that preeclampsia exacerbated by melatonin deficiency triggers hypoxic conditions, both mis/un-folded protein response, oxidative stress-induced DNA damage and apoptosis. Melatonin treatment provided significant therapeutic effects on fetal hearts via regulating all these stress response at cellular and molecular levels. Conclusion Melatonin may be considered as a potential molecule for development of preventive strategies to reduce the PE induced risk of cardiovascular diseases in offspring.
dc.identifier.doi10.1080/10641955.2020.1802595
dc.identifier.endpage443
dc.identifier.issn1064-1955
dc.identifier.issn1525-6065
dc.identifier.issue4
dc.identifier.pmid32791955
dc.identifier.scopus2-s2.0-85089448762
dc.identifier.scopusqualityQ2
dc.identifier.startpage429
dc.identifier.urihttps://doi.org/10.1080/10641955.2020.1802595
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26081
dc.identifier.volume39
dc.identifier.wosWOS:000559565100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofHypertension in Pregnancy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectPreeclampsia
dc.subjectheart
dc.subjectfetus
dc.subjectapoptosis
dc.subjectoxidative stress
dc.subjectmelatonin
dc.titleMelatonin regulates oxidative stress and apoptosis in fetal hearts of pinealectomised RUPP rats
dc.typeArticle

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