Does Retinal Neurodegeneration Seen in Diabetic Patients Begin in the Insulin Resistance Stage?

Basit Öğe Kaydı
dc.contributor.authorArikan, Sedat
dc.contributor.authorErsan, Ismail
dc.contributor.authorEroglu, Mustafa
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorTufan, Hasan Ali
dc.contributor.authorGencer, Baran
dc.contributor.authorKara, Selcuk
dc.date.accessioned2025-01-27T20:49:27Z
dc.date.available2025-01-27T20:49:27Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: To investigate whether retinal neurodegeneration and impairment in contrast sensitivity (CS), which have been demonstrated to begin in diabetic patients before the presence of signs of diabetic retinal vasculopathy, also occur in the stage of insulin resistance. Materials and Methods: The average, minimum and sectoral (inferior, superior, inferonasal, superonasal, inferotemporal and superotemporal) thicknesses of the ganglion cell-inner plexiform layer (GCIPL) measured using optical coherence tomography were compared between an insulin-resistant group and control group in order to evaluate the presence of retinal neurodegeneration. The CS of the two groups was also compared according to the logarithmic values measured at spatial frequencies of 1.5, 3, 6, 12 and 18 cycles per degree in photopic light using functional acuity contrast test (FACT). Results: Twenty-five eyes of 25 patients with insulin resistance (insulin resistant group) and 25 eyes of 25 healthy subjects (control group) were included in this study. There were no statistically significant differences between the two groups in any of the spatial frequencies in the FACT. The mean average GCIPL thickness and mean GCIPL thickness in the inferotemporal sector were significantly less in the insulin-resistant group when compared with the control group (mean average GCIPL thicknesses in the insulin-resistant and control groups were 83.6 +/- 4.7 mu m and 86.7 +/- 3.7 mu m respectively, p = 0.01; mean inferotemporal GCIPL thicknesses in the insulinresistant and control groups were 83 +/- 6.0 mu m and 86.7 +/- 4.6 mu m respectively, p = 0.02). Conclusion: Although it may not lead to functional visual impairment such as CS loss, the retinal neurodegeneration seen in diabetic patients may begin in the insulin resistance stage.
dc.identifier.doi10.4274/tjo.68888
dc.identifier.endpage269
dc.identifier.issn1300-0659
dc.identifier.issn2147-2661
dc.identifier.issue6
dc.identifier.pmid28050322
dc.identifier.scopus2-s2.0-85007489128
dc.identifier.scopusqualityN/A
dc.identifier.startpage264
dc.identifier.urihttps://doi.org/10.4274/tjo.68888
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25157
dc.identifier.volume46
dc.identifier.wosWOS:000393281800003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Ophthalmological Soc
dc.relation.ispartofTurk Oftalmoloji Dergisi-Turkish Journal of Ophthalmology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectInsulin resistance
dc.subjectretinal ganglion cell layer
dc.subjectcontrast sensitivity
dc.titleDoes Retinal Neurodegeneration Seen in Diabetic Patients Begin in the Insulin Resistance Stage?
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu