Investigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain

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dc.authorid0000-0002-4845-7910
dc.authorid0000-0003-1944-2477
dc.authorid0000-0001-8184-4691
dc.authorid0000-0002-2036-6929
dc.authorid0000-0002-6861-9163
dc.contributor.authorYuksel, Cihan
dc.contributor.authorAliravci, Isil D.
dc.contributor.authorKosan, Murat
dc.contributor.authorEsen, Sinem
dc.contributor.authorYenice Aktas, Sevinc
dc.contributor.authorKaya Terzi, Neslihan
dc.contributor.authorBerber, Ahmet Ali
dc.date.accessioned2026-02-03T12:00:02Z
dc.date.available2026-02-03T12:00:02Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: This study aimed to evaluate the therapeutic efficacy of intravesical tigecycline administration in a rat model of cystitis induced by a tigecycline-sensitive, extensively drug-resistant (XDR) Acinetobacter baumannii strain. Methods: Thirty-six female Wistar albino rats were inoculated intravesically with XDR A. baumannii to induce cystitis. Twenty-four rats that developed infection were divided into four groups: untreated control, saline irrigation, low-dose tigecycline (6.25 mg/kg), and high-dose tigecycline (25 mg/kg). Microbiological clearance was assessed via urine cultures on days 3 and 5. Bladder tissues were analyzed histopathologically and for genotoxicity using the Comet assay. Results: On day 5, microbiological clearance was significantly higher in tigecycline-treated groups compared to controls (p = 0.028). Histopathology revealed significantly more inflammation in the high-dose tigecycline group (p = 0.029). Genotoxicity was observed in both tigecycline groups, independent of dose (p < 0.05). Conclusions: Intravesical tigecycline demonstrated microbiological efficacy against XDR A. baumannii-induced cystitis. However, its inflammatory and genotoxic potential necessitates further preclinical evaluation.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [TTU-2024-4782]
dc.description.sponsorshipThis research was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit, project number: TTU-2024-4782.
dc.identifier.doi10.3390/antibiotics14060611
dc.identifier.issn2079-6382
dc.identifier.issue6
dc.identifier.pmid40558201
dc.identifier.scopus2-s2.0-105008923892
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.3390/antibiotics14060611
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34489
dc.identifier.volume14
dc.identifier.wosWOS:001515706800001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofAntibiotics-Basel
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectXDR
dc.subjectAcinetobacter baumannii
dc.subjecttigecycline
dc.subjectintravesical therapy
dc.subjectgenotoxicity
dc.subjectrat model
dc.titleInvestigation of Therapeutic Efficacy of Intravesical Tigecycline Administration in Rats with Cystitis Induced by Extensively Drug-Resistant (XDR), Tigecycline-Sensitive Acinetobacter baumannii Strain
dc.typeArticle

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