Alterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas

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dc.authoridKorgali, Esat/0000-0003-0318-0353
dc.contributor.authorKilinc, Devran
dc.contributor.authorÖzdemir, Öztürk
dc.contributor.authorOzdemir, Semra
dc.contributor.authorKorgali, Esat
dc.contributor.authorKoksal, Binnur
dc.contributor.authorUslu, Atilla
dc.contributor.authorGultekin, Yener E.
dc.date.accessioned2025-01-27T20:29:10Z
dc.date.available2025-01-27T20:29:10Z
dc.date.issued2012
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHypermethylated genomic DNA is a common feature in tumoral tissues, although the prevalence of this modification remains poorly understood. We aimed to determine the frequency of five tumor suppressor (TS) genes in prostate cancer and the correlation between promoter hypermethylation of these genes and low and high grade of prostate carcinomas. A total of 30 prostate tumor specimens were investigated for promoter methylation status of TS hypermethylated in cancer 1 (HIC1), death-associated protein kinase 1 (DAPK1), secreted frizzled-related protein 2 (SFRP2), cyclin-dependent kinase inhibitor 2A (p16), and O-6-methylguanine-DNA methyltransferase (MGMT) genes by using bisulfite modifying method. A high frequency of promoter hypermethylation was found in HIC1 (70.9%), SFRP2 (58.3%), and DAPK1 (33.3%) genes in tumor samples that were examined. The current data show high frequency of hypermethylation changes in HIC1, SFRP2, and DAPK1 genes in prostate carcinomas of high Gleason Score (GS).
dc.identifier.doi10.1089/dna.2011.1431
dc.identifier.endpage832
dc.identifier.issn1044-5498
dc.identifier.issn1557-7430
dc.identifier.issue5
dc.identifier.pmid22136354
dc.identifier.scopus2-s2.0-84861414700
dc.identifier.scopusqualityQ2
dc.identifier.startpage826
dc.identifier.urihttps://doi.org/10.1089/dna.2011.1431
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22848
dc.identifier.volume31
dc.identifier.wosWOS:000304312300028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofDna and Cell Biology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectEpigenetic Inactivation
dc.subjectDna Methylation
dc.subjectCancer
dc.subjectHypermethylation
dc.subjectExpression
dc.subjectEzh2
dc.subjectMethyltransferase
dc.subjectIdentification
dc.subjectTranscription
dc.subjectActivation
dc.titleAlterations in Promoter Methylation Status of Tumor Suppressor HIC1, SFRP2, and DAPK1 Genes in Prostate Carcinomas
dc.typeArticle

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