Hyaluronic acid and hyaluronic acid: Sucrose nanogels for hydrophobic cancer drug delivery

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dc.authoridCömert Önder, Ferah / 0000-0002-4037-1979
dc.authoridAy, Mehmet / 0000-0002-1095-1614
dc.authoridÖzpolat, Bülent / 0000-0001-8602-7463
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridAri, Betül / 0000-0003-3557-3055
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorAri, Betül
dc.contributor.authorCömert Önder, Ferah
dc.contributor.authorÖzpolat, Bülent
dc.contributor.authorAy, Mehmet
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:39:27Z
dc.date.available2025-01-27T20:39:27Z
dc.date.issued2019
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPorous and biodegradable hyaluronic acid (HA) nanogel and their copolymeric forms with sucrose (Suc), HA:Sucrose (HA:Suc) nanogels, were synthesized by employing glycerol diglycidyl ether (GDE) as crosslinker with a single step reaction in surfactant-free medium. The size of the nanogels was determined as 150 +/- 50 nm in dried state from SEM images and found to increase to about 540 +/- 47 nm in DI water measured with DLS measurements. The surface areas of HA and HA:Suc nanogels were measured as 18.07 +/- 2.4 and 32.30 +/- 6.1 m(2)/g with porosities of 3.58 +/- 1.8, and 9.44 +/- 3.1 nm via BET analysis, respectively. The zeta potentials for HA and HA:Suc nanogels were measured as -33 +/- 1.4 and -30 +/- 1.2 mV, respectively. The thermal degradation of both types of nanogels revealed similar trends, while hydrolytic degradation of the nanogels was about 22.7 +/- 02 wt% in 15 days. Both HA and HA:Suc nanogels were stable in blood up to 250 mu g/mL concentration with approximately 0.5 +/- 0.1% hemolysis ratio and 76 +/- 12% blood clotting indices, respectively. Finally, these nanogels were used as a sustained slow-release or long-term delivery system over 2 days for a hydrophobic cancer drug, 3-((E)-3-(4-hydroxyphenyl)acryloyl)-2H-chromen-2-on (A(#)) established by our group. The nanogels successfully delivered the model drug A at 10.43 +/- 2.12 mg/g for 2 days. (C) 2019 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [215S008]
dc.description.sponsorshipThe authors are grateful to The Scientific and Technological Research Council of Turkey (215S008) for financial support. Ferah Comert Onder also would like to thank to the Scientific and Technological Research Council of Turkey (TUBITAK-BIDEB 2214A program).
dc.identifier.doi10.1016/j.ijbiomac.2019.01.021
dc.identifier.endpage1157
dc.identifier.issn0141-8130
dc.identifier.issn1879-0003
dc.identifier.pmid30625351
dc.identifier.scopus2-s2.0-85059752378
dc.identifier.scopusqualityQ1
dc.identifier.startpage1150
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2019.01.021
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23953
dc.identifier.volume126
dc.identifier.wosWOS:000460710000129
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHyaluronic acid/sucrose
dc.subjectDegradable microgel/nanogels
dc.subjectCancer drug delivery
dc.subjectSustained delivery therapy
dc.titleHyaluronic acid and hyaluronic acid: Sucrose nanogels for hydrophobic cancer drug delivery
dc.typeArticle

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