Effect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis

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dc.contributor.authorJamialahmadi, Tannaz
dc.contributor.authorReiner, Zeljko
dc.contributor.authorSimental-Mendia, Luis E.
dc.contributor.authorAlmahmeed, Wael
dc.contributor.authorKarav, Sercan
dc.contributor.authorEid, Ali H.
dc.contributor.authorGiammarile, Francesco
dc.date.accessioned2025-01-27T20:27:40Z
dc.date.available2025-01-27T20:27:40Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackgroundPathogenesis of atherosclerosis is largely mediated by inflammatory process. Statins are lipid-lowering drugs which also have anti-inflammatory effects. 18 fluorine radiolabeled fluorodeoxyglucose (18 F-FDG) positron emission tomography-computed tomography (PET-CT) is considered to be a good indicator of arterial wall inflammation. Therefore, in this meta-analysis the role of statins on inflammatory process in the artery wall was evaluated using this method since its actual validity for this purpose is not yet well established.MethodsPubMed, Scopus, Web of Science, ClinicalTrials.gov, and Google Scholar databases were searched using MESH terms and keywords. Funnel plot, Begg's rank correlation, and Egger's weighted regression tests evaluated publication bias in the meta-analysis. In cases where funnel plot asymmetry was observed, the trim and fill method was used to check the input of potentially missing studies.ResultsFindings of 10 clinical trials involving 373 subjects showed a remarkable reduction of arterial wall 18 F-FDG uptake according to target-to-background ratio (TBR) index after treatment with statins. Subgroup analysis showed a significant decrease in TBR with high-intensity and non-significant reduction of TBR with low-to-moderate-intensity statin therapy.ConclusionTreatment with statins suppressed arterial wall inflammation as shown by using 18 F-FDG PET-CT.
dc.identifier.doi10.1186/s12950-024-00421-x
dc.identifier.issn1476-9255
dc.identifier.issue1
dc.identifier.pmid39696570
dc.identifier.scopus2-s2.0-85212388989
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12950-024-00421-x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22751
dc.identifier.volume21
dc.identifier.wosWOS:001379753900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJournal of Inflammation-London
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectStatins
dc.subjectAtherosclerosis
dc.subjectInflammation
dc.subject18F-FDG PET-CT
dc.subjectCardiovascular disease
dc.titleEffect of statins on arterial wall inflammation as assessed by 18F-FDG PET CT: an updated systematic review and meta-analysis
dc.typeArticle

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