Effect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice

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dc.authoridTEPE, Bektas/0000-0001-8982-5188
dc.authoridYILMAZ TUNCEL, NESE/0000-0003-2700-5840
dc.authoridTUNCEL, NECATI BARIS/0000-0001-9885-5063
dc.authoridGUNGOR, HUSEYIN/0000-0002-2506-3855
dc.contributor.authorTurgut, Nergiz Hacer
dc.contributor.authorMert, Derya Guliz
dc.contributor.authorKara, Haki
dc.contributor.authorEgilmez, Hatice Reyhan
dc.contributor.authorArslanbas, Emre
dc.contributor.authorTepe, Bektas
dc.contributor.authorGungor, Huseyin
dc.date.accessioned2025-01-27T20:20:36Z
dc.date.available2025-01-27T20:20:36Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractContext: Morus nigra L. (Moraceae) has various uses in traditional medicine. However, the effect of M. nigra on cognitive impairment has not been investigated yet. Objective: The objective of this study is to determine the phenolic acid content and DNA damage protection potential of M. nigra leaf extract and to investigate the extract effect on cognitive impairment and oxidative stress in aging mice. Materials and methods: Phenolic acid content was determined by quantitative chromatographic analysis. DNA damage protection potential was evaluated on pBR322 plasmid DNA. Thirty-two Balb-C mice were randomly divided into four groups (control, d-galactose, d-galactose + M. nigra 50, and d-galactose + M. nigra 100). Mice were administered d-galactose (100 mg/kg, subcutaneous) and M. nigra (50 or 100 mg/kg, orally) daily for 8 weeks. Behavioral responses were evaluated with Morris water maze. Activities of antioxidant enzymes and levels of malondialdehyde (MDA) were assayed in serum, brain, and liver. Results: In extract, vanillic (632.093 mu g/g) and chlorogenic acids (555.0 mu g/g) were determined. The extract between 0.02 and 0.05 mg/mL effectively protected all DNA bands against the hazardous effect of UV and H2O2. Morus nigra significantly improved learning dysfunctions (p< 0.01), increased memory retention (p < 0.01), reduced MDA levels (p < 0.05), and elevated SOD, GPx, and CAT activities (p < 0.05) compared with the d-galactose group. Discussion and conclusion: These results show that M. nigra has the potential in improving cognitive deficits in mice and that M. nigra may be useful to suppress aging, partially due to its scavenging activity of free radicals and high antioxidant capacity.
dc.description.sponsorshipCumhuriyet University Scientific Research Project (CUBAP, Sivas, Turkey) [V-012]
dc.description.sponsorshipThe authors report that they have no conflicts of interest. This study was supported by Cumhuriyet University Scientific Research Project V-012 (CUBAP, Sivas, Turkey).
dc.identifier.doi10.3109/13880209.2015.1101476
dc.identifier.endpage1064
dc.identifier.issn1388-0209
dc.identifier.issn1744-5116
dc.identifier.issue6
dc.identifier.pmid26510817
dc.identifier.scopus2-s2.0-84945362998
dc.identifier.scopusqualityQ1
dc.identifier.startpage1052
dc.identifier.urihttps://doi.org/10.3109/13880209.2015.1101476
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21760
dc.identifier.volume54
dc.identifier.wosWOS:000373977600015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPharmaceutical Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectmemory retention
dc.subjectAntioxidant
dc.subjectlearning
dc.subjectphenolic acid
dc.titleEffect of black mulberry (Morus nigra) extract treatment on cognitive impairment and oxidative stress status of d-galactose-induced aging mice
dc.typeArticle

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