Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

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dc.contributor.authorOyardi, Ozlem
dc.contributor.authorSavage, Paul B.
dc.contributor.authorAlper Akçalı
dc.contributor.authorErturan, Zayre
dc.contributor.authorBozkurt-Guzel, Cagla
dc.date.accessioned2025-01-27T20:22:24Z
dc.date.available2025-01-27T20:22:24Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCeragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms. Since colistin resistance has become a worldwide problem, the need for new treatment agents has been increasing steadily. Therefore, this study aimed to investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid Antibiotics) (CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant Gram negative isolates from Turkey. Experiments were performed by using broth microdilution method against Klebsiella pneumoniae, Morganella morganii, Pseudomonas aeruginosa and Stenotrophomonas maltophilia isolates. All microorganisms except for three isolates were identified as multidrug resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64 mu g/ml). Nevertheless, the antimicrobial activity of CSA-8 was not significant. In conclusion, ceragenins appear to be a good candidate as antimicrobial therapy in the presence of multidrug (including colistin) resistant microorganisms.
dc.identifier.doi10.26650/IstanbulJPharm.2018.400730
dc.identifier.endpage72
dc.identifier.issn2587-2087
dc.identifier.issue3
dc.identifier.startpage68
dc.identifier.trdizinid310695
dc.identifier.urihttps://doi.org/10.26650/IstanbulJPharm.2018.400730
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/310695
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21870
dc.identifier.volume48
dc.identifier.wosWOS:000456247200003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherIstanbul Univ, Fac Pharmacy
dc.relation.ispartofIstanbul Journal of Pharmacy
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectCeragenins
dc.subjectcolistin resistance
dc.subjectgram negative pathogens
dc.titleCeragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria
dc.typeArticle

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