Renoprotective Effect of Humic Acid on Renal Ischemia-Reperfusion Injury: An Experimental Study in Rats

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dc.authoridgulpinar, murat tolga/0000-0001-9420-3009
dc.authoridSılan, Coşkun/0000-0002-8352-6571
dc.authoridAkbas, Alpaslan/0000-0003-1470-5952
dc.contributor.authorAkbas, Alpaslan
dc.contributor.authorSılan, Coşkun
dc.contributor.authorGulpinar, Murat Tolga
dc.contributor.authorSancak, Eyup Burak
dc.contributor.authorOzkanli, Sidika Seyma
dc.contributor.authorCakir, Dilek Ulker
dc.date.accessioned2025-01-27T20:46:04Z
dc.date.available2025-01-27T20:46:04Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHumic acid is an antioxidant molecule used in agriculture and livestock breeding, as well as in medicine. Our aim was to investigate the potential renoprotective effects of humic acid in a renal ischemia reperfusion model. Twenty-one rats were randomly divided into three equal groups. Intraperitoneal serum or humic acid was injected at 1, 12, and 24 h. Non-ischemic group I was evaluated as sham. The left renal artery was clamped in serum (group II) and intraperitoneal humic acid (group III) to subject to left renal ischemic reperfusion procedure. Ischemia and reperfusion time was 60 min for each. Total antioxidant status, total oxidative status, oxidative stress index, and ischemia-modified albumin levels were analyzed biochemically from the serum samples. Kidneys were evaluated histopatologically and immunohistochemically. Biochemical results showed that total oxidative status, ischemia-modified albumin, and oxidative stress index levels were significantly decreased, but total antioxidant status was increased in the humic acid group (III) compared with the ischemia group (II) On histopathological examination, renal tubular dilatation, tubular cell damage and necrosis, dilatation of Bowman's capsule, hyaline casts, and tubular cell spillage were decreased in the humic acid group (III) compared with the ischemia group (II). Immunohistochemical results showed that apoptosis was deteriorated in group III. Renal ischemia reperfusion injury was attenuated by humic acid administration. These observations indicate that humic acid may have a potential therapeutic effect on renal ischemia reperfusion injury by preventing oxidative stress.
dc.description.sponsorshipResearch Fund of Canakkale Onsekiz Mart University [159]
dc.description.sponsorshipThis work was supported by the Research Fund of Canakkale Onsekiz Mart University. Project Number 159.
dc.identifier.doi10.1007/s10753-015-0185-2
dc.identifier.endpage2048
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue6
dc.identifier.pmid25985848
dc.identifier.scopus2-s2.0-84946474890
dc.identifier.scopusqualityQ1
dc.identifier.startpage2042
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0185-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24802
dc.identifier.volume38
dc.identifier.wosWOS:000364223800004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectkidney
dc.subjecthumic acid
dc.subjectischemia reperfusion
dc.titleRenoprotective Effect of Humic Acid on Renal Ischemia-Reperfusion Injury: An Experimental Study in Rats
dc.typeArticle

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