Synthesis, characterization and modification of Gum Arabic microgels for hemocompatibility and antimicrobial studies

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbas Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorFarooq, Muhammad
dc.contributor.authorSağbaş, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSiddiq, Mohammad
dc.contributor.authorTürk, Mustafa
dc.contributor.authorAktaş, Nahit
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:39:27Z
dc.date.available2025-01-27T20:39:27Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGum Arabic (GA) microgels were successfully prepared via reverse micellization method with high yield (78.5 +/- 5.0%) in 5-100 mu m size range using divinyl sulfone (DVS) as a crosslinker. The GA microgels were degraded hydrolytically 22.8 +/- 3.5% at pH 1 in 20 days, whereas no degradation was observed at pH 7.4 and pH 9 at 37 degrees C. By using diethylenetriamine (DETA), and taurine (TA) as chemical modifying agents, GA microgels were chemically modified as GA-DETA and GA-TA, and the zeta potential values of 5.2 +/- 4.1 and -24.8 +/- 1.3 mV were measured, respectively in comparison to -27.3 +/- 4.2 mV for GA. Moreover, blood compatibility of GA, GA-TA, and GA-DETA microgels was tested via in vitro protein adsorption, % hemolysis ratio, and blood clotting index. All the microgels were hemocompatible with% hemolysis ratio between 0.23 to 2.05, and the GA microgels were found to be highly compatible with a blood clotting index of 81 +/- 40. The biocompatibility of GA, GA-DETA and GA-Taurine microgels against L929 fibroblast cells also revealed 84.4, 89.1, and 67.0% cell viability, respectively, at 25.0 mu g/mL concentration, suggesting great potential in vivo biomedical applications up to this concentration. In addition, 5 and 10 mgImL minimum inhibition concentrations of protonated GA-DETA microgels (GA-DETA-HCl) were determined against E. coli and S. aureus, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [TUBITAK 2216]
dc.description.sponsorshipM. Farooq is grateful to The Scientific and Technological Research Council of Turkey (TUBITAK) for the support under the TUBITAK 2216 research fellowship program.
dc.identifier.doi10.1016/j.carbpol.2016.09.052
dc.identifier.endpage389
dc.identifier.issn0144-8617
dc.identifier.issn1879-1344
dc.identifier.pmid27842837
dc.identifier.scopus2-s2.0-84988351598
dc.identifier.scopusqualityQ1
dc.identifier.startpage380
dc.identifier.urihttps://doi.org/10.1016/j.carbpol.2016.09.052
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23951
dc.identifier.volume156
dc.identifier.wosWOS:000388110900043
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofCarbohydrate Polymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectGum Arabic microgels/nanogels
dc.subjectModifiable GA particle
dc.subjectDegradable/biocompatible GA microgel
dc.subjectAntimicrobial GA microgel
dc.titleSynthesis, characterization and modification of Gum Arabic microgels for hemocompatibility and antimicrobial studies
dc.typeArticle

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