TLR2 and TLR4 molecules and antigen- presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post- hatch period

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dc.authorid0000-0003-4128-8947en_US
dc.authorscopusid55871787100en_US
dc.authorwosid-en_US
dc.contributor.authorEren, Ülker
dc.contributor.authorKum, Sadiye
dc.contributor.authorNazlıgül, Ahmet
dc.contributor.authorGüleş, Özay
dc.contributor.authorAka, Ebru
dc.contributor.authorYıldız, Mustafa
dc.contributor.authorZorlu, Seçil
dc.date.accessioned2023-04-18T08:24:31Z
dc.date.available2023-04-18T08:24:31Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractChickens do not have lymph nodes. Gut-associated lymphoid tissue is the major immu-nological organization for the digestive system. Cecal tonsils are an important part of this organization. This study is a descriptive and experimental study that was conducted to determine the histological development of the cecal tonsils and the distribution of Toll- like receptor (TLR) 2, TLR4 and antigen- presenting cells during the first 2 weeks of the chick's life. The tissue sections were stained using Crossmon's triple technique, Gordon and Sweet's silver impregnation, and streptavidin- biotin- peroxidase complex methods. The classical tonsil framework with fossa and tonsillar units were observed in 4 days cecal tissue. The web of reticular fibres forming the stroma of the tissue had the impression that the lymphoid cells filling in time. The development of cecal tonsil was completed histologically on the day 10 and following day 14 samples. Regardless of the antigenic stimulation, TLR2, TLR4 and CD83, major histocompatibility complex (MHC) class II molecules are present in proximal cecal tissue. However, CD83- positive dendritic cells in the germinal centre were first distinguished on day 7. Furthermore, the high antigen presentation capacity of the cecum with an intense MHC class II molecule expression was determined. Histological and immunohistochemical findings in this study revealed that both innate and adaptive cecal defence mechanisms were in the learning period during the first 2 weeks. The learning period of innate immunity may require more detailed research. However, the results obtained in this study will be taken into consideration in the vaccination programmes in chicks.en_US
dc.identifier.citationEren, U., Kum, S., Nazlıgül, A., Güleş, O., Aka, E., Yıldız, M., & Zorlu, S. (2022). TLR2 and TLR4 molecules and antigen-presenting cell compositions in cecal tonsils of broiler chicks (gallus gallus domesticus) in the first two weeks of the post-hatch period. Journal of Veterinary Medicine Series C: Anatomia Histologia Embryologia, 51(1), 125-135. doi:10.1111/ahe.12773en_US
dc.identifier.doi10.1111/ahe.12773
dc.identifier.endpage135en_US
dc.identifier.issn0340-2096
dc.identifier.issn1439-0264
dc.identifier.issue1en_US
dc.identifier.pmid34866215
dc.identifier.scopus2-s2.0-85120458768
dc.identifier.startpage125en_US
dc.identifier.urihttps://doi.org/10.1111/ahe.12773
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4031
dc.identifier.volume51en_US
dc.identifier.wosWOS:000726453700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYıldız, Mustafa
dc.language.isoen
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofJournal of Veterinary Medicine Series C: Anatomia Histologia Embryologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCecal tonsilsen_US
dc.subjectChicken_US
dc.subjectDendritic cellsen_US
dc.subjectMHC class IIen_US
dc.subjectTLR2en_US
dc.subjectTLR4en_US
dc.titleTLR2 and TLR4 molecules and antigen- presenting cell compositions in cecal tonsils of broiler chicks (Gallus gallus domesticus) in the first two weeks of the post- hatch period
dc.typeArticle

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