Roles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis

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dc.authoridBudak, Ferah/0000-0001-7625-9148
dc.authoridDemir, Nesrin/0000-0003-3658-0185
dc.authoridTezcan, Gulcin/0000-0002-5956-8755
dc.authoridKanbur, Ertan/0000-0001-8399-8942
dc.contributor.authorHiz, Pinar
dc.contributor.authorKanbur, Ertan
dc.contributor.authorDemir, Nesrin
dc.contributor.authorAkalin, Halis
dc.contributor.authorCagan, Eren
dc.contributor.authorPashazadeh, Mehrdat
dc.contributor.authorBal, Salih Haldun
dc.date.accessioned2025-01-27T20:29:29Z
dc.date.available2025-01-27T20:29:29Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe secretion of interleukin (IL)-1 family cytokines is one of the most potent and earliest pro-inflammatory responses triggered by brucellosis. However, the roles of the most recently discovered IL-1 family members, IL-36, IL-37, and IL-38, in the transition into the chronic form of brucellos is remain largely unknown. Therefore, in this study, the roles of IL-36, IL-37, and IL-38 in brucella infections and their effects on the transition from the acute to chronic form of the disease were investigated. Using peripheral blood samples from 40 patients with acute brucellosis, 40 patients with chronic brucellosis, and 40 healthy control subjects, we analysed the serum concentrations of secreted IL-36, IL-37, and IL-38 using ELISA. The findings were confirmed by using RT-qPCR to analyse the mRNA levels of the genes encoding IL-36, IL-37, and IL-38 in peripheral blood mononuclear cells (PBMCs) from 10 randomly selected patients from each of the three groups. Our results showed that serum IL-37 (p < 0.001) and IL-38 (p < 0.001) concentrations were lower in patients with brucellosis than in the healthy controls. In addition, serum IL-37 and IL-38 concentrations were higher in the chronic patient group than in the acute patient group. The mRNA expression levels of IL-37 and IL1F10, genes that encode IL-38, did not affect serum cytokine secretion levels. This result suggests that the high secretion levels of IL-37 and IL-38 may be related to the progression into the chronic form of brucellosis. Our findings will aid in clarifying the mechanism of the transition of brucellosis from the acute to the chronic form of the disease.
dc.description.sponsorshipBursa Uludag University, Turkey, BAP Unit [DDP(T)-2017/13]
dc.description.sponsorshipThis study was supported by Bursa Uludag University, Turkey, BAP Unit (Project number: DDP(T)-2017/13).
dc.identifier.doi10.1016/j.cyto.2020.155211
dc.identifier.issn1043-4666
dc.identifier.issn1096-0023
dc.identifier.pmid32736334
dc.identifier.scopus2-s2.0-85088654333
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.cyto.2020.155211
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22962
dc.identifier.volume135
dc.identifier.wosWOS:000572835200021
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Ltd- Elsevier Science Ltd
dc.relation.ispartofCytokine
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectBrucellosis
dc.subjectIL-36
dc.subjectIL-37
dc.subjectIL-38
dc.subjectAcute
dc.subjectChronic
dc.titleRoles of novel IL-1 family (IL-36, IL-37, and IL-38) members in chronic brucellosis
dc.typeArticle

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