Modulatory role of GSTM1 null genotype on the frequency of micronuclei in pesticide-exposed agricultural workers

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dc.authoridSEN, Alaattin/0000-0002-8444-376X
dc.authoridTumer, Tugba/0000-0002-1740-4867
dc.contributor.authorTumer, Tugba Boyunegmez
dc.contributor.authorSavranoglu, Seda
dc.contributor.authorAtmaca, Pelin
dc.contributor.authorTerzioglu, Gulsurn
dc.contributor.authorSen, Alaattin
dc.contributor.authorArslan, Sevki
dc.date.accessioned2025-01-27T20:50:20Z
dc.date.available2025-01-27T20:50:20Z
dc.date.issued2016
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIn this study, we aimed to investigate the extent of genotoxic risk and the association between null GSTM1/GSTT1 and GSTP1 Ile105Val variants and cellular DNA damage, as measured by micronucleus (MN) assay in a group of agricultural workers from Denizli, Turkey. Peripheral blood samples were collected from 116 subjects, including 58 workers who were occupationally exposed to pesticides and 58 healthy unexposed controls. The MN frequencies of each individual were assessed by cytokinesis-blocked micronuclei assays on lymphocytes. Genotypes for different GST variants were determined using polymerase chain reaction-based methods. A significant 3.4-fold increase in MN frequency was observed in workers compared with the controls (p < 0.001). Among the GST genotypes, only the GSTM1 null genotype was found to be significantly associated with an increased MN frequency in workers (p = 0.01). Individuals with a concomitant null GSTM1/GSTT1 genotype demonstrated a significant (p = 0.01) increase in MN frequency compared with those with functional isozymes in the exposed worker group. The association of the GSTM1 null genotype with higher MN frequency suggests that it may be a modifier of genotoxic risk in individuals exposed to pesticides and may thus be a candidate susceptibility biomarker for human biomonitoring studies.
dc.description.sponsorshipCanakkale Onsekiz Mart University [2010-113]
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Canakkale Onsekiz Mart University [grant number 2010-113].
dc.identifier.doi10.1177/0748233715599876
dc.identifier.endpage1951
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue12
dc.identifier.pmid26381689
dc.identifier.scopus2-s2.0-85000868686
dc.identifier.scopusqualityQ2
dc.identifier.startpage1942
dc.identifier.urihttps://doi.org/10.1177/0748233715599876
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25469
dc.identifier.volume32
dc.identifier.wosWOS:000389113500004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAgricultural workers
dc.subjectGSTs
dc.subjectpolymorphisms
dc.subjectpesticide
dc.subjectMN frequency
dc.titleModulatory role of GSTM1 null genotype on the frequency of micronuclei in pesticide-exposed agricultural workers
dc.typeArticle

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