Superporous hyaluronic acid cryogel composites embedding synthetic polyethyleneimine microgels and Halloysite Nanotubes as natural clay

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridDemirci, Şahin / 0000-0001-7083-1481
dc.contributor.authorDemirci, Şahin
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:49:55Z
dc.date.available2025-01-27T20:49:55Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description3rd International Conference on Bio-Based Polymers and Composites (BiPoCo) -- AUG 28-SEP 01, 2016 -- Szeged, HUNGARY
dc.description.abstractIn this study, the preparation of hyaluronic acid (HA) cryogels were carried out in the presence of polyethyleneimine (PEI) microgels, and Halloysite Nanotubes (HNTs) clays separately resulted in the corresponding cryogel composites under cryogenic condition ( < 0 degrees C). The synthesized HA/PEI cryogel microgel composites, and HA/HNTs cryogel composites were characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR), and by the swelling studies to compare % pore volume and porosity values of the composite materials. The swelling properties and moisture content of HA cryogel, HA/PEI and HA/HNTs cryogel composites were determined at wound healing pH conditions such as pH 5.4, 7.4, and 9 at 37.5 degrees C. The highest swelling capacity was reached at pH 9 with 4854 +/- 50% swelling (S%) within few seconds. The blood compatibility of the HA cryogel and its' PEI microgel and HNT embedding composite were found to be hemocompatible with maximum of 2.4% hemolysis ratio, and demonstrated high antitrombogenic activity varying in the range of 10.22-17.67 blood clotting indexes. Therefore, these materials can be used as drug carriers, and tested for a model drug, sodium diclofenac (SDF) that can be released from HA/PEI cryogel composites with a linear fashion with long term releasing capabilities up to 9.22 mg/g within 20 h at physiological conditions, pH 7.4, 37.5 degrees C.
dc.identifier.doi10.1016/j.eurpolymj.2017.04.022
dc.identifier.endpage784
dc.identifier.issn0014-3057
dc.identifier.issn1873-1945
dc.identifier.scopus2-s2.0-85018743222
dc.identifier.scopusqualityQ1
dc.identifier.startpage775
dc.identifier.urihttps://doi.org/10.1016/j.eurpolymj.2017.04.022
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25355
dc.identifier.volume93
dc.identifier.wosWOS:000407186200069
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofEuropean Polymer Journal
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHyaluronic acid (HA)
dc.subjectPolyethyleneimine (PEI) microgels
dc.subjectHalloysite nanotubes (HNTs) clay composite
dc.subjectNatural superporous cryogel/hydrogel
dc.subjectDrug delivery
dc.titleSuperporous hyaluronic acid cryogel composites embedding synthetic polyethyleneimine microgels and Halloysite Nanotubes as natural clay
dc.typeConference Object

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