An innovative and mass-sensitive quartz tuning fork (QTF) biosensor for GFAP detection: A novel approach for traumatic brain injury diagnosis

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dc.authoridÖzcan, Burcu / 0000-0002-5123-5972
dc.authoridUludağ Anıl, İnci / 0000-0003-4296-2657
dc.authoridSezgintürk, Mustafa Kemal / 0000-0003-3042-1087
dc.contributor.authorÖzcan, Burcu
dc.contributor.authorUludağ Anıl, İnci
dc.contributor.authorÜnal, Mehmet Altay
dc.contributor.authorArı, Fikret
dc.contributor.authorSezgintürk, Mustafa Kemal
dc.contributor.authorÖzkan, Sibel Ayşıl
dc.date.accessioned2025-05-29T02:54:03Z
dc.date.available2025-05-29T02:54:03Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe early diagnosis and management of traumatic brain injury (TBI) are dependent upon the early and precise detection of glial fibrillary acidic protein (GFAP). In this investigation, a novel biosensor based on quartz tuning forks (QTF) was introduced and functionalized with 11-mercaptoundecanoic acid (11-MUA). This biosensor is designed to facilitate the highly sensitive and selective detection of GFAP in human serum. In contrast to conventional neuroimaging methods, which are resource-intensive and frequently inaccessible in emergency situations, this innovative biosensor offers a portable, cost-effective, and efficient alternative for rapid GFAP measurement. The detection range of the system is 0.05 fg mL−1 to 25 fg mL−1. The Atomic Force Microscopy (AFM) was utilized to visualize the morphology of the QTF surface during the immobilization steps of the sensor. The developed biosensor presented advantages such as ability to determine GFAP concentrations at femtogram level, reproducibility and repeatability (standard deviation: ±0.0935966 Hz, and coefficient of variation: 7.91 %). This study highlights a significant progression in biosensing technology, providing an exceptionally sensitive and scalable platform for diagnosing neurological disorders, with potential uses in point-of-care environments. © 2025 The Authors
dc.description.sponsorshipCOMU-BAP
dc.description.sponsorshipBAP-ADEP, (TSA-2022-2653)
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ, (FBA-2024-4657)
dc.description.sponsorshipÇanakkale Onsekiz Mart Üniversitesi, ÇOMÜ
dc.identifier.doi10.1016/j.biosx.2025.100614
dc.identifier.issn2590-1370
dc.identifier.scopus2-s2.0-105001974834
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.biosx.2025.100614
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29906
dc.identifier.volume24
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Ltd
dc.relation.ispartofBiosensors and Bioelectronics: X
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250529
dc.subjectGFAP
dc.subjectQuartz tuning fork
dc.subjectTraumatic brain injury
dc.titleAn innovative and mass-sensitive quartz tuning fork (QTF) biosensor for GFAP detection: A novel approach for traumatic brain injury diagnosis
dc.typeArticle

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